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AZD4635

Name: AZD4635
Brand: TargetMol
SKU: T4265
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4265Cas No. 1321514-06-0

Alias HTL1071

AZD4635 (HTL1071) is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).

AZD4635

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Purity: 99.90%

Catalog No. T4265Alias HTL1071Cas No. 1321514-06-0

AZD4635 (HTL1071) is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$312	In Stock	In Stock
100 mg	$480	-	In Stock
500 mg	$1,060	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

AZD4635 AI Summary

AZD4635 exhibits antagonist activity at the adenosine A2A receptor with a Ki value of 1.7 nM. It shows potent bioactivity as an adenosine receptor ligand, demonstrating high affinity for A2AAR (Ki of 1.72 nM), moderate affinity for A2BAR (Ki of 55.8 nM), and significantly lower affinity for A1AR (Ki of 131.1 nM) and A3AR (Ki of 22685.8 nM). The compound also exhibits a selectivity ratio of 76.1 for A2AAR over A1AR and A2BAR. Additionally, AZD4635 demonstrates antitumor activity with a tumor growth inhibition (TGI) of 56.0% against mouse 4T1 cells, acts as an antagonist at A2AAR by inhibiting CGS21680-induced cAMP production with an IC50 of 298.8 nM, and inhibits IL-2 production in human T-cells with an EC50 of 725.1 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AZD4635 (HTL1071) is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).
Targets&IC50	A2A receptor:Ki: 1.7 nM
Synonyms	HTL1071

Chemical Properties

Molecular Weight	315.73
Formula	C₁₅H₁₁ClFN₅
Cas No.	1321514-06-0
Smiles	Cc1cc(cc(Cl)n1)-c1nnc(N)nc1-c1ccc(F)cc1
Relative Density.	1.387 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (263.83 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1673 mL	15.8363 mL	31.6726 mL	158.3632 mL
5 mM	0.6335 mL	3.1673 mL	6.3345 mL	31.6726 mL
10 mM	0.3167 mL	1.5836 mL	3.1673 mL	15.8363 mL
20 mM	0.1584 mL	0.7918 mL	1.5836 mL	7.9182 mL
50 mM	0.0633 mL	0.3167 mL	0.6335 mL	3.1673 mL
100 mM	0.0317 mL	0.1584 mL	0.3167 mL	1.5836 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc