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Anti-Granzyme H/GZMH Antibody (5P967)
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Catalog No. TMAY-00668
Alias CTSGL2, CTLA1, CSP-C, CGL-2, CGL2, CCP-X
Anti-Granzyme H/GZMH Antibody (5P967) is a Mouse antibody targeting Granzyme H/GZMH. Anti-Granzyme H/GZMH Antibody (5P967) can be used in ELISA.
Anti-Granzyme H/GZMH Antibody (5P967)
Anti-Granzyme H/GZMH Antibody (5P967)
😃Good
Catalog No. TMAY-00668Alias CTSGL2, CTLA1, CSP-C, CGL-2, CGL2, CCP-X
Anti-Granzyme H/GZMH Antibody (5P967) is a Mouse antibody targeting Granzyme H/GZMH. Anti-Granzyme H/GZMH Antibody (5P967) can be used in ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μL | $199 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Granzyme H/GZMH Antibody (5P967) is a Mouse antibody targeting Granzyme H/GZMH. Anti-Granzyme H/GZMH Antibody (5P967) can be used in ELISA. |
| Synonyms | CTSGL2, CTLA1, CSP-C, CGL-2, CGL2, CCP-X |
| Ig Type | Mouse IgG2a |
| Clone | 5P967 |
| Reactivity | Human |
| Specificity | Human Granzyme H No cross-reactivity in ELISA with Human Granzyme B Human cell lysate (293 cell line) |
| Application | |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granzyme H / GZMH (rh Granzyme H / GZMH; NP_219491.1; Met 1-Leu 246). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M, and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural killer (NK) compartment of the immune system. In adenovirus-infected cells in which granzyme B (gzmB) and downstream apoptosis pathways are inhibited, granzyme H directly cleaves the adenovirus DNA-binding protein (DBP), a viral component required for viral DNA replication. This virus demonstrated that gzmH directly induces an important decay in viral DNA replication. Interestingly, gzmH also cleaves the adenovirus 1K assembly protein, a major inhibitor of gzmB, and relieves gzmB inhibition. Granzyme H has a very high amino acid identity (>9%) with many portions of the granzyme B sequence, particularly near the amino terminus of the molecule despite performing a distinct enzymic function. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Granzyme H / GZMH protein |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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