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Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody
Catalog No. TMAB-11286 Copy Product Info
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Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SLP76 (Tyr113). Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody can be used in WB.
Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-11286
Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SLP76 (Tyr113). Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody can be used in WB.
Anti-Phospho-SLP76
(Tyr113) Polyclonal Antibody
(Tyr113) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SLP76 (Tyr113). Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Pig,Cow,Horse,Rabbit,Sheep) |
| Verified Activity | Sample: JurkaT (Human) Cell Lysate at 30 μg Spleen (Mouse) Lysate at 40 μg Primary: Anti-phospho-SLP76 (Tyr113) (TMAB-11286) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 75 kD Observed band size: 75 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. Post-translational modifications : Phosphorylated after T-cell receptor activation by ZAP-70. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav’s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human SLP76 around the phosphorylation site of Tyr113 |
| Antigen Species | Human |
| Gene Name | LCP2 |
| Gene ID | |
| Protein Name | Lymphocyte cytosolic protein 2 |
| Uniprot ID | |
| Function | Involved in T-cell antigen receptor mediated signaling. |
| Molecular Weight | Theoretical: 75 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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