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ATX inhibitor 1

Name: ATX inhibitor 1
Brand: TargetMol
SKU: T10410
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10410Cas No. 2225892-70-4

ATX inhibitor 1 is a potent ATX inhibitor with IC50 values of 1.23 nM (FS-3) and 2.18 nM (bis-pNPP).

ATX inhibitor 1

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Purity: 99.52%

Catalog No. T10410Cas No. 2225892-70-4

ATX inhibitor 1 is a potent ATX inhibitor with IC50 values of 1.23 nM (FS-3) and 2.18 nM (bis-pNPP).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$129	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$328	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

ATX inhibitor 1 AI Summary

ATX inhibitor 1 shows high metabolic stability in both rat and human liver microsomes, with the parent compound maintaining high levels after preincubation with NADPH. It exhibits a long half-life in both species, indicating sustained presence in the system. In Sprague-Dawley rats, ATX inhibitor 1 displays a moderate volume of distribution, clearance rate, and area under the curve (AUC) values. When administered at different doses, it maintains consistent pharmacokinetic parameters including Tmax, Cmax, and AUC. Regarding bioactivity, ATX inhibitor 1 demonstrates potent inhibition of ENPP2 with low IC50 values across various cell types and substrates, indicating significant therapeutic potential against the target enzyme..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ATX inhibitor 1 is a potent ATX inhibitor with IC50 values of 1.23 nM (FS-3) and 2.18 nM (bis-pNPP).
Targets&IC50	bis-pNPP:2.18 nM , FS3:1.23 nM

Chemical Properties

Molecular Weight	501.3
Formula	C₂₁H₂₃Cl₂N₂O₆P
Cas No.	2225892-70-4
Smiles	C(OC(=O)N1CCC(C(NC2=CC=C(CP(=O)(O)O)C=C2)=O)CC1)C3=CC(Cl)=CC(Cl)=C3
Relative Density.	1.501 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (498.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9948 mL	9.9741 mL	19.9481 mL	99.7407 mL
5 mM	0.3990 mL	1.9948 mL	3.9896 mL	19.9481 mL
10 mM	0.1995 mL	0.9974 mL	1.9948 mL	9.9741 mL
20 mM	0.0997 mL	0.4987 mL	0.9974 mL	4.9870 mL
50 mM	0.0399 mL	0.1995 mL	0.3990 mL	1.9948 mL
100 mM	0.0199 mL	0.0997 mL	0.1995 mL	0.9974 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc