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1-(7-carbamimidamidoheptyl)guanidine 2HCl

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Catalog No. T50092Cas No. 2193061-39-9
Alias 1,1'-(Heptane-1,7-diyl)diguanidine 2HCl, 1-(7-carbamimidamidoheptyl)guanidine dihydrochloride

1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3). It is used in studies of stem cell differentiation, tumors and neurodegenerative diseases.

1-(7-carbamimidamidoheptyl)guanidine 2HCl

1-(7-carbamimidamidoheptyl)guanidine 2HCl

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Catalog No. T50092Alias 1,1'-(Heptane-1,7-diyl)diguanidine 2HCl, 1-(7-carbamimidamidoheptyl)guanidine dihydrochlorideCas No. 2193061-39-9
1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3). It is used in studies of stem cell differentiation, tumors and neurodegenerative diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$86InquiryInquiry
5 mg$198InquiryInquiry
10 mg$298InquiryInquiry
25 mg$475InquiryInquiry
50 mg$672InquiryInquiry
100 mg$912InquiryInquiry
200 mg$1,190InquiryInquiry
1 mL x 10 mM (in DMSO)$190InquiryInquiry
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Product Introduction

Bioactivity
Description
1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3). It is used in studies of stem cell differentiation, tumors and neurodegenerative diseases.
Synonyms1,1'-(Heptane-1,7-diyl)diguanidine 2HCl, 1-(7-carbamimidamidoheptyl)guanidine dihydrochloride
Chemical Properties
Molecular Weight287.23
FormulaC9H24Cl2N6
Cas No.2193061-39-9
SmilesNC(NCCCCCCCNC(N)=N)=N.[H]Cl.[H]Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (174.08 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4815 mL17.4077 mL34.8153 mL174.0765 mL
5 mM0.6963 mL3.4815 mL6.9631 mL34.8153 mL
10 mM0.3482 mL1.7408 mL3.4815 mL17.4077 mL
20 mM0.1741 mL0.8704 mL1.7408 mL8.7038 mL
50 mM0.0696 mL0.3482 mL0.6963 mL3.4815 mL
100 mM0.0348 mL0.1741 mL0.3482 mL1.7408 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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