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Sulfanitran

Name: Sulfanitran
Brand: TargetMol
SKU: T1248
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1248Cas No. 122-16-7

Sulfanitran is a sulfonamide antibiotic used in the poultry industry.

Sulfanitran

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Purity: 99.60%

Catalog No. T1248Cas No. 122-16-7

Sulfanitran is a sulfonamide antibiotic used in the poultry industry.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$51	In Stock	In Stock
500 mg	$92	In Stock	In Stock
1 g	$133	In Stock	-
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.60%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Sulfanitran AI Summary

Sulfanitran has demonstrated varied bioactivity across multiple biological targets and assays. It significantly influences human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles with an activity level of 116.0%. Additionally, it acts as an inhibitor in assays involving several proteins such as human JMJD2E, TDP1, ALDH1A1, Menin-MLL interaction in leukemia, HPGD, ROR gamma transcriptional activity, Cytochrome P450 3A4, N370S glucocerebrosidase, and S16 Schwann cell PMP22 intronic element. The compound also showed efficacy in antiviral assays against Foot and Mouth Disease Virus and Ebola Virus entry. In transport assays, Sulfanitran inhibits sodium fluorescein uptake in OATP1B1-transfected CHO cells by 61.58% and in OATP1B3-transfected CHO cells by 88.89% at 10 µM concentration. However, it does not significantly inhibit human BSEP, MRP3, and MRP4 as indicated by the high IC50 values (> 133,000.0 nM) in the respective membrane vesicle transport assays. Concerning its antiviral activity, Sulfanitran inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells. At a 10 µM concentration, it shows modest inhibition rates of 5.41% and -0.21%, respectively, after 48 hours. Nevertheless, the IC50 values suggest it may require higher concentrations for significant activity against SARS-CoV-2 (> 20000.0 nM and 19952.62 nM). The compound also inhibits SARS-CoV-2 3CL-Pro protease by 6.588% at a concentration of 20 µM. Additionally, Sulfanitran exhibits inhibitory activity against human HDAC6 in enzymatic assays, showing inhibition percentages of 17.7% and 5.02% with commercial and custom peptide substrates, respectively, indicating its potential HDAC6 inhibitory bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Sulfanitran is a sulfonamide antibiotic used in the poultry industry.

Chemical Properties

Molecular Weight	335.34
Formula	C₁₄H₁₃N₃O₅S
Cas No.	122-16-7
Smiles	CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)[N+]([O-])=O
Relative Density.	1.5g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (164.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9820 mL	14.9102 mL	29.8205 mL	149.1024 mL
5 mM	0.5964 mL	2.9820 mL	5.9641 mL	29.8205 mL
10 mM	0.2982 mL	1.4910 mL	2.9820 mL	14.9102 mL
20 mM	0.1491 mL	0.7455 mL	1.4910 mL	7.4551 mL
50 mM	0.0596 mL	0.2982 mL	0.5964 mL	2.9820 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4910 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc