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CTLA-4 Protein, Human, Recombinant (His & Avi), Biotinylated

Catalog No. TMPK-00112
Synonyms: IDDM12, ICOS, CD152, GRD4, CTLA4, CELIAC3, GSE, ALPS5

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

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CTLA-4 Protein, Human, Recombinant (His & Avi), Biotinylated
Pack Size Availability Price/USD Quantity
100 μg 5 days $ 465.00
500 μg 5 days $ 1,850.00
1 mg 5 days $ 3,100.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
Species Human
Expression System HEK293 Cells
Tag C-His-Avi
Accession Number P16410
Synonyms IDDM12, ICOS, CD152, GRD4, CTLA4, CELIAC3, GSE, ALPS5
Construction Lys36-Asp161
Protein Purity > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight 16.3 kDa (predicted). Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result.
Endotoxin < 1 EU/μg by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

References and Literature

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Keywords

CTLA-4 Protein, Human, Recombinant (His & Avi), Biotinylated ALPS-5 GRD-4 IDDM12 ICOS CD 152 CD152 GRD4 CTLA-4 ALPS 5 IDDM 12 CTLA4 CELIAC3 CTLA 4 CELIAC 3 IDDM-12 GRD 4 GSE CELIAC-3 ALPS5 CD-152 recombinant recombinant-proteins proteins protein

 

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