HRSP12 Protein, Human, Recombinant (His)

Name: HRSP12 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01007
Rating: 4.5 (1 reviews)

(Synonyms: UK114 Antigen Homolog, Ribonuclease UK114, PSP, p14.5, HRSP12, Heat-Responsive Protein 12, 14.5 kDa Translational Inhibitor Protein) Copy Product Info

Synonyms: UK114 Antigen Homolog, Ribonuclease UK114, PSP, p14.5, HRSP12, Heat-Responsive Protein 12, 14.5 kDa Translational Inhibitor Protein

Catalog No. TMPJ-01007 Copy Product Info

Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.

HRSP12 Protein, Human, Recombinant (His)

Pack Size	Price	USA Stock	Global Stock
10 µg	$97	35 days	35 days
20 µg	$148	35 days	35 days
50 µg	$270	35 days	35 days
100 µg	$482	35 days	35 days
200 µg	$868	35 days	35 days
500 µg	$1,900	35 days	35 days
1 mg	$2,730	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.
Species	Human
Expression System	E. coli
Tag	N-6xHis
Accession Number	P52758
Amino Acid	Met1-Leu137
Construction	Met1-Leu137
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 1 mM DTT, 10% Glycerol, pH 8.0.
Synonyms	UK114 Antigen Homolog, Ribonuclease UK114, PSP, p14.5, HRSP12, Heat-Responsive Protein 12, 14.5 kDa Translational Inhibitor Protein
Research Background	Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.

Chemical Properties

Molecular Weight

16 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.