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1-Methylhistamine dihydrochloride

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Catalog No. T8790Cas No. 6481-48-7

1-Methylhistamine dihydrochloride is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer's disease patients as well as those with hypersomnia and other neurological conditions.

1-Methylhistamine dihydrochloride
Other Forms of 1-Methylhistamine dihydrochloride:
1-MethylhistamineT13487501-75-7
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1-Methylhistamine dihydrochloride

🥰Excellent
Purity: 99.31%
Catalog No. T8790Cas No. 6481-48-7
1-Methylhistamine dihydrochloride is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer's disease patients as well as those with hypersomnia and other neurological conditions.
Pack SizePriceAvailabilityQuantity
5 mg$33In Stock
10 mg$51In Stock
25 mg$97In Stock
50 mg$178In Stock
100 mg$268In Stock
1 mL x 10 mM (in DMSO)$34In Stock
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Purity:99.31%
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COA LCMS HPLC HNMR

Product Introduction

Bioactivity
Description
1-Methylhistamine dihydrochloride is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer's disease patients as well as those with hypersomnia and other neurological conditions.
Chemical Properties
Molecular Weight198.09
FormulaC6H13Cl2N3
Cas No.6481-48-7
SmilesCl.Cl.CN1C=NC(CCN)=C1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 12 mg/mL (60.58 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.0482 mL25.2411 mL50.4821 mL252.4105 mL
5 mM1.0096 mL5.0482 mL10.0964 mL50.4821 mL
10 mM0.5048 mL2.5241 mL5.0482 mL25.2411 mL
20 mM0.2524 mL1.2621 mL2.5241 mL12.6205 mL
50 mM0.1010 mL0.5048 mL1.0096 mL5.0482 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

InhibitorinhibitHuman Endogenous MetaboliteEndogenousMetaboliteEndogenous Metabolite1-Methylhistamine Dihydrochloride1Methylhistamine dihydrochloride1-Methylhistamine1 Methylhistamine dihydrochloride
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