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Anti-Phospho-ESR1 (Ser118) Antibody (8R937)
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Catalog No. TMAH-00897
Alias Phospho-ESR1 (S118), Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER
Anti-Phospho-ESR1 (Ser118) Antibody (8R937) is an antibody targeting Phospho-ESR1 (Ser118). Anti-Phospho-ESR1 (Ser118) Antibody (8R937) can be used in ELISA, IHC.
Anti-Phospho-ESR1 (Ser118) Antibody (8R937)
Anti-Phospho-ESR1 (Ser118) Antibody (8R937)
😃Good
Catalog No. TMAH-00897Alias Phospho-ESR1 (S118), Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER
Anti-Phospho-ESR1 (Ser118) Antibody (8R937) is an antibody targeting Phospho-ESR1 (Ser118). Anti-Phospho-ESR1 (Ser118) Antibody (8R937) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Chemical Properties
| Description | Anti-Phospho-ESR1 (Ser118) Antibody (8R937) is an antibody targeting Phospho-ESR1 (Ser118). Anti-Phospho-ESR1 (Ser118) Antibody (8R937) can be used in ELISA, IHC. |
| Alias | Phospho-ESR1 (S118), Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER |
| Ig Type | Rabbit IgG |
| Clone | 8R937 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00897 diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Isoform 1]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.; Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Binds to ERE and inhibits isoform 1. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-ESR1 (S118) |
| Antigen Species | Human |
| Gene ID | 2099 |
| Uniprot ID | |
| Biology Area | Signal Transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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