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Anti-NPPB Antibody (6G519) is a Mouse antibody targeting NPPB. Anti-NPPB Antibody (6G519) can be used in ELISA, IHC.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $209 | 7-10 days | |
100 μg | $349 | 7-10 days |
Description | Antibody Type: Mouse Monoclonal Application: ELISA, IHC Reactivity: Human |
Alias | γ-brain natriuretic peptide, NPPB, Natriuretic peptides B, Gamma-brain natriuretic peptide, BNP |
Ig Type | IgG2b |
Clone | 6G519 |
Reactivity | Human |
Verified Activity | 1. Immunohistochemistry of paraffin-embedded human brain using TMAH-00823 in 30μg/ml dilute concentrations. 2. Immunohistochemistry of paraffin-embedded human heart using TMAH-00823 in 30μg/ml dilute concentrations. 3. Immunohistochemistry of paraffin-embedded human brain using TMAH-00823 in 30μg/ml dilute concentrations. 4. Immunohistochemistry of paraffin-embedded human heart using TMAH-00823 in 30μg/ml dilute concentrations. |
Application | ELISA, IHC |
Antibody Type | Monoclonal |
Host Species | Mouse |
Subcellular Localization | [NT-proBNP]: Secreted.; [proBNP(3-108)]: Secreted.; [Brain natriuretic peptide 32]: Secreted.; [BNP(3-32)]: Secreted. |
Construction | Hybridoma Monoclonal Antibody |
Purification | Protein G purified |
Appearance | Liquid |
Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
Purity | >95% |
Research Background | Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3. May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32. May have a role in cardio-renal homeostasis. Able to promote the production of cGMP. |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein: Human NPPB Protein |
Antigen Species | Human |
Gene ID | 4879 |
Uniprot ID | |
Biology Area | Signal Transduction |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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