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4A-BFA-11

Name: 4A-BFA-11
Brand: TargetMol
SKU: T214998
Rating: 4.5 (1 reviews)

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4A-BFA-11 is a folate-targeted PEG-MMAE conjugate with specific binding affinity for the folate receptor α (FR-α) (KD= 106.7 nM). It achieves tumor accumulation by combining PEG-mediated long circulation (EPR effect) with folate receptor targeting. At the tumor site, 4A-BFA-11 undergoes enzymatic cleavage to release the active payload, ensuring precise action. In HeLa mouse models, 4A-BFA-11 effectively delivers, targets, and regulates the release of MMAE within tumor tissues. This compound can be applied in research involving cervical cancer, ovarian cancer, and lung cancer.

4A-BFA-11

Pack Size	Price	USA Stock	Global Stock	Quantity
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50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	4A-BFA-11 is a folate-targeted PEG-MMAE conjugate with specific binding affinity for the folate receptor α (FR-α) (KD= 106.7 nM). It achieves tumor accumulation by combining PEG-mediated long circulation (EPR effect) with folate receptor targeting. At the tumor site, 4A-BFA-11 undergoes enzymatic cleavage to release the active payload, ensuring precise action. In HeLa mouse models, 4A-BFA-11 effectively delivers, targets, and regulates the release of MMAE within tumor tissues. This compound can be applied in research involving cervical cancer, ovarian cancer, and lung cancer.
Targets & IC50	FRα:106.7 nM (Kd)
In vitro	4A-BFA-11 exhibits antiproliferative activity in HeLa, SK-OV-3, and A549 cells, with IC 50 values of 37.62, 28.8, and 15.1 nM, respectively (72h).
In vivo	Administered via intravenous injection once weekly for a duration of 2 weeks, 4A-BFA-11 at doses of 0.4 and 0.8 mg/kg effectively inhibits tumor growth in the HeLa mouse cervical cancer model.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: 4A-BFA-11 in vivo | 4A-BFA-11 in vitro