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GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.

  • BL-1020 Mesylate
    T26834916898-61-8In house
    BL-1020 Mesylate (CYP-1020 Mesylate) is an orally available GABA A receptor agonist and D2 antagonist that decreases dopamine activity and enhances GABAA activity.BL-1020 Mesylate has been used in the study of schizophrenia, Alzheimer's disease, and bi-directional cognitive impairment.
    • $293 TargetMol
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  • Halothane
    T0954151-67-7
    Halothane (Anestan) is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required.
    • $45
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  • Valproic acid sodium salt
    T16021069-66-5
    Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, Valproic acid sodium salt increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproic acid sodium salt may also affect potassium channels, thereby creating a direct membrane-stabilizing effect.
    • $42
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  • Nikethamide
    T004859-26-7
    Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overtreatments, before the advent of end
    • $29
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  • (+)-BORNEOL
    T5734464-43-7
    (+)-BORNEOL (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM.
    • $50
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  • 6-Methoxyflavanone
    TN31743034-04-6
    6-Methoxyflavanone (6-MeOF) is A positive allosteric modulator of the GABA response of human recombinant GABA A receptor, with antianxiety and anti-inflammatory activity, and can be used to reduce cisplatin induced neuropathic pain.
    • $40
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  • DL-Menthol
    T297989-78-1
    DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities.
    • $42
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  • γ-Acetylenic GABA hydrochloride
    T40659L103451-26-9In house
    γ-Acetylenic GABA hydrochloride is a GABA transaminase inhibitor.
    • $50
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  • Cholesterol myristate
    T80401989-52-2
    Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the inward-rectifier potassium ion channel.
    • $30
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  • Penicillin G sodium salt
    T095869-57-8
    Penicillin G sodium(Benzylpenicillin sodium) salt is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
    • $47
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  • 3,4,5-Trimethoxycinnamic acid
    T298390-50-6
    3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
    • $29
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  • Sarmazenil
    T1684478771-13-8In house
    Sarmazenil (Ro 15-3505) is a partial inverse agonist at the benzodiazepine receptor with pro-convulsant properties and is used in the study of chronic hepatic encephalopathy (HE).
    • $293 TargetMol
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  • Acetoxyvalerensre
    TN677381397-67-3
    Acetoxyvalerensre (acetylvalerenolic acid) (acetylvalerenolic acid) is a derivative of valerenic acid, which is a a GABAA receptor modulator.
    • $133
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  • Nerisopam
    T28159102771-12-0In house
    Nerisopam is an agonist of gamma-aminobutyric acid (GABA) receptor.
    • $142
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  • Suritozole
    T8568110623-33-1
    Suritozole (MDL-26479) is a negative modulator at the gamma-aminobutyric acidA (GABAA) receptor
    • $133
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  • NS-2710
    T28197184220-36-8In house
    NS-2710 is a non-selective GABA(A) receptor partial agonist for the study of anxiety disorders.
    • $293 TargetMol
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  • ELB-139
    T27252188116-08-7In house
    ELB-139 is a GABAA receptor agonist that can be used to study depression and epilepsy.
    • $293 TargetMol
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  • Suriclone
    T2888753813-83-5In house
    Suriclone (RP 31264) is a selective cyclic pyrrolidone analog with sedative and anxiolytic activity, but not significant sedative effects.Suriclone shows its effects by modulating GABA-A receptors.
    • $146
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  • Muscimol HBr
    T2065718174-72-6
    Muscimol HBr (Agarin HBr) is an agonist of GABAA receptor.
    • $122
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  • 2'MeO6MF
    T888789112-85-6
    2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response. 2'MeO6MF has anxiolytic and sedative effects.
    • $79
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  • SCS
    T233393232-36-8
    SCS is a GABAA receptor antagonist.
    • $40
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  • 6,7-dimethylisatin
    T7756820205-43-0
    6,7-Dimethylisatin (6,7-dimethyl-1H-indole-2,3-dione) inhibits hGAT3 with IC50 of 108 μM. 6,7-Dimethylisatin also inhibits hBGT1, hGAT2.
    • $195
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  • Anxiolytic/nonsedative agent-1
    T23445355022-97-8
    Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo.
    • $58
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  • Fengabine
    T2731080018-06-0In house
    Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.
    • $76
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  • Pazinaclone
    T28303103255-66-9In house
    Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.
      6-8weeks
      Inquiry
    • Panadiplon
      T28294124423-84-3In house
      Panadiplon (FG 10571) is a selective gamma-aminobutyric acid receptor agonist and partial agonist of 5GABAA, a benzodiazepine receptor, used in the treatment of anxiety disorders.Panadiplon exhibits selectivity for 5GABAA receptors versus 1GABAA receptors.
      • $143
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    • Ru-32514
      T1277990807-98-0In house
      Ru-32514 is a benzodiazepine receptor agonist that partially reverses stress-induced arousal in mice and is used in the study of neurological disorders.
      • $293 TargetMol
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    • Golexanolone
      T254582089238-18-4In house
      Golexanolone (Golexanolona) is a novel GABA-A receptor-modulating steroid antagonist that reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in rats with chronic hyperammonemia, and may be used to study hepatic encephalopathy.
      • $293
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    • Imidazenil
      T8971151271-08-8
      Imidazenil is an modulator of GABA-A that blocks the sedative effects without lowering the convulsion threshold.
      • $101
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    • Propanidid
      T341461421-14-3In house
      Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure.
      • $36 TargetMol
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    • U 89843A
      T23481157013-32-6In house
      Positive allosteric modulator of GABAA receptors
      • $39 TargetMol
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    • Homocarnosine acetate
      T32098L
      Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation
      • $87
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    • AZD 3043
      T30248579494-66-9In house
      AZD 3043 (THRX 918661) is a variant modulator of the γ-aminobutyric acid type A receptor, a novel sedative-hypnotic and a potential short-acting anesthetic that produces hypnosis and EEG suppression in rats.AZD 3043 potentiates the γ-aminobutyric acid type A receptor and inhibits neuronal nicotinic acetylcholine receptors.
      • $293 TargetMol
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    • Dipropofol
      TNU06852416-95-7
      Dipropofol (4,4-Bis(2,6-di-isopropylphenol)) is a small molecule GABAA receptor agonist that can be used to study epilepsy.
      • $45
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    • Chlorothymol
      T2024289-68-9
      Chlorothymol (AI3-00120) is a disinfectant used in oral.
      • $40
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    • Baclofen hydrochloride
      T863028311-31-1
      Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
      • $133
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    • Lirequinil
      T27838143943-73-1In house
      Lirequinil (Ro 41-3696) is a small molecule GABAA receptor agonist used to study neurological disorders.
      • $160
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    • T-2000
      T2890097846-21-4In house
      T-2000 (DMMDPB) is a GABA receptor agonist that can be used to study myoclonus and essential tremor.
        6-8weeks
        Inquiry
      • PZ-II-029
        T28479164025-44-9
        PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.
        • $85
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      • RWJ-51204
        T16811205701-85-5In house
        RWJ-51204 is a selective adenosine A2A receptor antagonist and a partial agonist of GABA(A) receptor (IC50: 0.2-2 nM). It has neuroprotective and movement-improving effects and can be used in research related to Parkinson's disease.
        • $350
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      • NO-711ME
        T24540127586-66-7
        NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.
        • $148
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      • Divaplon
        T2718690808-12-1In house
        Divaplon is a GABA receptor agonist (IC50: 0.056 µM) that displays non-sedating anxiolytic behavioral characteristics in a rat model of anxiety.
        • $146
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      • 6-Hydroxyflavanone
        TN13084250-77-5
        6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A receptors. 6-Hydroxyflavanone has anti-injury sensory properties in a streptozotocin-induced diabetic neuropathy model. in a streptozotocin-induced diabetic neuropathy model with anti-injury sensory properties.
        • $50
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      • Losigamone
        T27845112856-44-7In house
        Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.
        • $75
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      • DMCM hydrochloride
        T110611215833-62-7In house
        DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
        • $31
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      • Broflanilide
        T106181207727-04-5In house
        Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM).
        • $51
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      • BPDBA
        T26891312281-74-6In house
        BPDBA is an effective, selective, and non-competitive inhibitor of the betaine GABA transporter (BGT-1), displaying inhibitory activity against human BGT-1 and mouse GAT2, with IC50 values of 20 μM and 35 μM, respectively.
        • $68
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      • (E)-GABAB receptor antagonist 1
        T111371611483-29-4In house
        (E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM. GABAB receptor antagonist 1 is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors.
        • $195
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      • Alpidem
        T2660082626-01-5In house
        Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family. Alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. Alpidem has nanomolar binding affinity for both the central benzodiaze
        • $56
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      • Glabridin
        T340359870-68-7
        Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
        • $31
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