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Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody
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Catalog No. TMAB-10477
Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CDKN1A/p21 (Ser130). Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody
Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody
😃Good
Catalog No. TMAB-10477
Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CDKN1A/p21 (Ser130). Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CDKN1A/p21 (Ser130). Anti-Phospho-CDKN1A/p21 (Ser130) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasmic and Nuclear. |
| Tissue Specificity | Expressed in all adult tissues, with 5-fold lower levels observed in the brain. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human P21 around the phosphorylation site of Ser130 |
| Antigen Species | Human |
| Gene Name | CDKN1A |
| Gene ID | |
| Protein Name | Cyclin-dependent kinase inhibitor 1 |
| Uniprot ID | |
| Function | May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. |
| Molecular Weight | Theoretical: 18 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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