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Lefradafiban

Name: Lefradafiban
Brand: TargetMol
SKU: T27808
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27808Cas No. 149503-79-7

Alias BIBU-104, BIBU104, BIBU 104

Lefradafiban(BIBU-104) is an oral platelet glycoprotein IIb/IIIa receptor antagonist for the study of angina pectoris and acute coronary syndromes.

Lefradafiban

🥰Excellent

Purity: 98.92%

Catalog No. T27808Alias BIBU-104, BIBU104, BIBU 104Cas No. 149503-79-7

Lefradafiban(BIBU-104) is an oral platelet glycoprotein IIb/IIIa receptor antagonist for the study of angina pectoris and acute coronary syndromes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$205	In Stock	In Stock
5 mg	$497	In Stock	In Stock
10 mg	$690	In Stock	In Stock
25 mg	$1,000	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.92%

ee:100%

Appearance:Solid

Color:White

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Lefradafiban(BIBU-104) is an oral platelet glycoprotein IIb/IIIa receptor antagonist for the study of angina pectoris and acute coronary syndromes.
In vivo	Lefradafiban (30, 45, and 60 mg; oral; three times daily for 48 hours; patients with stable angina undergoing angioplasty) is an effective oral glycoprotein IIb/IIIa receptor blocker.[1]
Synonyms	BIBU-104, BIBU104, BIBU 104

Chemical Properties

Molecular Weight	439.46
Formula	C₂₃H₂₅N₃O₆
Cas No.	149503-79-7
Smiles	C(NC(OC)=O)(=N)C1=CC=C(C=C1)C2=CC=C(OC[C@@H]3C[C@@H](CC(OC)=O)C(=O)N3)C=C2
Relative Density.	1.32g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (102.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2755 mL	11.3776 mL	22.7552 mL	113.7760 mL
5 mM	0.4551 mL	2.2755 mL	4.5510 mL	22.7552 mL
10 mM	0.2276 mL	1.1378 mL	2.2755 mL	11.3776 mL
20 mM	0.1138 mL	0.5689 mL	1.1378 mL	5.6888 mL
50 mM	0.0455 mL	0.2276 mL	0.4551 mL	2.2755 mL
100 mM	0.0228 mL	0.1138 mL	0.2276 mL	1.1378 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc