Anti-XRN1 Antibody (9Y814) is a Mouse antibody targeting XRN1. Anti-XRN1 Antibody (9Y814) can be used in WB.

IgG1, k

9Y814

Human (predicted:Mouse)

Sample:
Lane 1: K562 cell lysates
Lane 2: MCF-7 cell lysates
Primary: Anti-XRN1 (TMAB-14224) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 193 kD
Observed band size: 245 kD

WB: 1:500-2000

Monoclonal

Recombinant Protein: human XRN1 between 1455-1706 amino acids

Human

XRN1

5'-3' exoribonuclease 1

Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent- and salt-resistant nucleoskeletal structure.