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CL-82198

🥰Excellent
Catalog No. T14978Cas No. 307002-71-7

CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1' pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs.

CL-82198
Other Forms of CL-82198:
CL 82198 hydrochlorideT411791188890-36-9
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CL-82198

🥰Excellent
Purity: 95.91%
Catalog No. T14978Cas No. 307002-71-7
CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1' pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs.
Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$67In Stock
25 mg$155In Stock
50 mg$255In Stock
100 mg$397In Stock
200 mg$582In Stock
500 mg$913In Stock
1 mL x 10 mM (in DMSO)$43In Stock
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Purity:95.91%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1' pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs.
In vitro
CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells[3]. CL-82198 (10 μM; 24 hours) obviously reduces LS174 cell migration[1].
In vivo
CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) treatment avoids and decelerates MLI-induced osteoarthritis progression.
Chemical Properties
Molecular Weight302.37
FormulaC17H22N2O3
Cas No.307002-71-7
SmilesO=C(NCCCCN1CCOCC1)c1cc2ccccc2o1
Relative Density.1.159 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (330.72 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3072 mL16.5360 mL33.0721 mL165.3603 mL
5 mM0.6614 mL3.3072 mL6.6144 mL33.0721 mL
10 mM0.3307 mL1.6536 mL3.3072 mL16.5360 mL
20 mM0.1654 mL0.8268 mL1.6536 mL8.2680 mL
50 mM0.0661 mL0.3307 mL0.6614 mL3.3072 mL
100 mM0.0331 mL0.1654 mL0.3307 mL1.6536 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

MMP-13MMPMatrix metalloproteinasesInhibitorinhibitCL-82198CL82198CL 82198
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