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Anti-NPC2 Antibody (6B875)
😃Good
Catalog No. TMAY-02564
Alias Niemann-Pick disease, type C2, HE1, AU045843, AA408070, 2700012J19Rik
Anti-NPC2 Antibody (6B875) is a Mouse antibody targeting NPC2. Anti-NPC2 Antibody (6B875) can be used in IHC-P.
Anti-NPC2 Antibody (6B875)
Anti-NPC2 Antibody (6B875)
😃Good
Catalog No. TMAY-02564Alias Niemann-Pick disease, type C2, HE1, AU045843, AA408070, 2700012J19Rik
Anti-NPC2 Antibody (6B875) is a Mouse antibody targeting NPC2. Anti-NPC2 Antibody (6B875) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-NPC2 Antibody (6B875) is a Mouse antibody targeting NPC2. Anti-NPC2 Antibody (6B875) can be used in IHC-P. |
| Alias | Niemann-Pick disease, type C2, HE1, AU045843, AA408070, 2700012J19Rik |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 6B875 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human NPC2 in human epididymis with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human NPC2 in human kidney with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NPC2 (rh NPC2; TMPY-01114; NP_006423.1; Met1-Leu151). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0 |
| Research Background | Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human NPC2 Protein (TMPY-01114) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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