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E 0747
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Catalog No. T24021Cas No. 99599-78-7
Alias L 29065, E-0747, E0747, E 747
E 0747 (E0747) is a new antiarrhythmic compound that inhibits arrhythmias by inhibiting Na channels in cardiac cells.
E 0747
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Purity: 95.17%
Catalog No. T24021Alias L 29065, E-0747, E0747, E 747Cas No. 99599-78-7
E 0747 (E0747) is a new antiarrhythmic compound that inhibits arrhythmias by inhibiting Na channels in cardiac cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 2 mg | $436 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:95.17%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | E 0747 (E0747) is a new antiarrhythmic compound that inhibits arrhythmias by inhibiting Na channels in cardiac cells. |
| In vivo | Intravenous injection of 3 mg/kg of E-0747 through a femoral vein cannula over a period of seconds using four canine models of ventricular arrhythmia: digitalis, sedation, arrhythmia, and heart failure concluded that E-0747 inhibits arrhythmia by inhibiting Na channels in cardiomyocytes[1];At a frequency of 1 Hz and a concentration higher than 3 X 10(-7) M, E-0747 decreased the maximum rate of rise (Vmax) of the action potential of Purkinje fibers in porcine heart, whereas the resting membrane potential was unchanged, and E-0747 inhibited Vmax in a rate-dependent manner.The inhibition was about 50% at a concentration of 3 X 10(-6) M with a stimulus of 3.3 Hz.[4]. |
| Synonyms | L 29065, E-0747, E0747, E 747 |
| Molecular Weight | 421.92 |
| Formula | C21H28ClN3O4 |
| Cas No. | 99599-78-7 |
| Smiles | O=C1NC2(C(=O)N1CCCN3CCC(O)CC3)C4=CC(Cl)=CC=C4OC(C)(C)C2 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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