Anti-MRG15 Polyclonal Antibody

Anti-MRG15 Polyclonal Antibody is a Rabbit antibody targeting MRG15. Anti-MRG15 Polyclonal Antibody can be used in WB.

IgG

Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)

Sample: Ovary (Mouse) Lysate at 40 μg
Primary: Anti-MRG15 (TMAB-08991) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kD
Observed band size: 41 kD

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human MRG15

Human

MORF4L1

Mortality factor 4-like protein 1

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.