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AGF347
Catalog No. T214901 Copy Product Info
🥰Excellent
AGF347 is a potent multitarget antifolate that acts on serine hydroxymethyltransferase (SHMT)2 located in mitochondria and SHMT1 in the cytoplasm, while inhibiting de novo purine synthesis. This compound induces apoptosis, suppresses the mTOR signaling pathway, reduces glutathione (GSH) levels, and increases reactive oxygen species (ROS) production. AGF347 effectively inhibits the proliferation of both Cisplatin-sensitive and resistant epithelial ovarian cancer (EOC) cells and demonstrates antitumor activity in SKOV3 EOC xenograft mouse models. It is a valuable agent for ovarian cancer research.
AGF347
Copy Product Info🥰Excellent
Catalog No. T214901
AGF347 is a potent multitarget antifolate that acts on serine hydroxymethyltransferase (SHMT)2 located in mitochondria and SHMT1 in the cytoplasm, while inhibiting de novo purine synthesis. This compound induces apoptosis, suppresses the mTOR signaling pathway, reduces glutathione (GSH) levels, and increases reactive oxygen species (ROS) production. AGF347 effectively inhibits the proliferation of both Cisplatin-sensitive and resistant epithelial ovarian cancer (EOC) cells and demonstrates antitumor activity in SKOV3 EOC xenograft mouse models. It is a valuable agent for ovarian cancer research.
AGF347
Cas No. 2294820-23-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AGF347 is a potent multitarget antifolate that acts on serine hydroxymethyltransferase (SHMT)2 located in mitochondria and SHMT1 in the cytoplasm, while inhibiting de novo purine synthesis. This compound induces apoptosis, suppresses the mTOR signaling pathway, reduces glutathione (GSH) levels, and increases reactive oxygen species (ROS) production. AGF347 effectively inhibits the proliferation of both Cisplatin-sensitive and resistant epithelial ovarian cancer (EOC) cells and demonstrates antitumor activity in SKOV3 EOC xenograft mouse models. It is a valuable agent for ovarian cancer research. |
| Molecular Weight | 473.46 |
| Formula | C22H24FN5O6 |
| Cas No. | 2294820-23-6 |
| Smiles | C(CCCC1=CC(F)=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C1)N2C3=C(C=C2)NC(N)=NC3=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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