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Dihydro-5-azacytidine

Catalog No. T40713 CAS 62488-57-7

Synonyms: DHAC, NSC264880, Dihydro-5-azacytidine

Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.

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Dihydro-5-azacytidine Chemical Structure

Dihydro-5-azacytidine, CAS 62488-57-7

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Description	Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.
In vitro	Methylation research reveals that administering an LD 10 dose of [3H]DHAC induces 25.06% DNA hypomethylation in L1210/0 cells and 46.32% in L1210/dCK(-) deoxycytidine kinase mutant cells, relative to their controls[2]. Furthermore, Dihydro-5-azacytidine (DHAC) competes with cytidine triphosphate for RNA integration, resulting in ribosomal breakdown and impaired protein synthesis[1].
In vivo	In tumor-bearing mice (injected with L1210/0 cells), receiving an LD 10 dose of Dihydro-5-azacytidine (DHAC; 1500 mg/kg) results in a peak plasma concentration of 317 μM, followed by biexponential elimination characterized by a half-life (t 1/2) of 1.03 hours (α phase) and 5 hours (β phase)[2].

Synonyms	DHAC, NSC264880, Dihydro-5-azacytidine
Molecular Weight	246.223
Formula	C8H14N4O5
CAS No.	62488-57-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3(4):417-21. 2. W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice. Cancer Chemother Pharmacol. 1988;21(2):117-21.

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Keywords

Dihydro-5-azacytidine 62488-57-7 NSC-264880 DHAC Dihydro5azacytidine NSC264880 NSC 264880 Dihydro 5 azacytidine inhibitor inhibit

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