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Degarelix is a peptide and selective GnRH (human gonadotropin-releasing hormone) receptor antagonist that treats prostate cancer by lowering testosterone levels in the body.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $64 | In Stock | |
5 mg | $155 | In Stock | |
10 mg | $259 | In Stock | |
25 mg | $415 | In Stock | |
50 mg | $582 | In Stock | |
100 mg | $913 | In Stock | |
200 mg | $1,230 | In Stock |
Description | Degarelix is a peptide and selective GnRH (human gonadotropin-releasing hormone) receptor antagonist that treats prostate cancer by lowering testosterone levels in the body. |
In vitro | Degarelix significantly reduced cell viability in multiple prostate-derived cell lines (1 nM–10 μM, 0–72 h), with no inhibitory effect on PC-3 cells[1].Degarelix suppressed prostate cell growth by inducing apoptosis (10 μM, 0–72 h)[1]. |
In vivo | In rats, a single subcutaneous dose of Degarelix (1–10 mg/kg, sc) caused dose-dependent testosterone suppression lasting >30 days[1].In prostate cancer patients, Degarelix (240 mg loading dose followed by monthly 80 mg sc) rapidly reduced serum testosterone to castrate levels (≤0.5 ng/mL), without the agonist-related hormone surge, and maintained suppression for at least 1 month[1]. |
Alias | FE200486 free base, FE 200486 free base |
Molecular Weight | 1632.26 |
Formula | C82H103ClN18O16 |
Cas No. | 214766-78-6 |
Smiles | C([C@@H](NC([C@@H](NC([C@@H](CC1=CC=C(NC(N)=O)C=C1)NC([C@H](CC2=CC=C(NC(=O)[C@@H]3CC(=O)NC(=O)N3)C=C2)NC([C@@H](NC([C@@H](CC=4C=CC=NC4)NC([C@@H](CC5=CC=C(Cl)C=C5)NC([C@@H](CC6=CC7=C(C=C6)C=CC=C7)NC(C)=O)=O)=O)=O)CO)=O)=O)=O)CC(C)C)=O)CCCCNC(C)C)(=O)N8[C@H](C(N[C@@H](C(N)=O)C)=O)CCC8 |
Relative Density. | 1.325 g/cm3 (Predicted) |
Storage | keep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
Solubility Information | H2O: 4 mg/mL (2.45 mM), Sonication is recommended. DMSO: 8 mg/mL (4.9 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O/DMSO
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