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SRT 2183

🥰Excellent
Catalog No. T16932Cas No. 1001908-89-9

SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).

SRT 2183

SRT 2183

🥰Excellent
Purity: 97.86%
Catalog No. T16932Cas No. 1001908-89-9
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$46In StockIn Stock
2 mg$66In StockIn Stock
5 mg$109In StockIn Stock
10 mg$168In StockIn Stock
25 mg$297In StockIn Stock
50 mg$453In StockIn Stock
100 mg$655In StockIn Stock
1 mL x 10 mM (in DMSO)$113In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.86%
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Product Introduction

Bioactivity
Description
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
Targets&IC50
SIRT1:0.36 μM (EC1.5)
In vitro
SRT2183 leads to increased mRNA levels of pro-apoptosis and DNA-damage-response genes, accompanied by accumulation of phospho-H2A.X levels.?Combination of SRT2183 with panobinostat enhanced the anti-growth and anti-survival effects mediated by either compound alone.?Quantitative-PCR confirmed that the panobinostat in combination with SRT2183, SRT501 or resveratrol leads to greater upregulation of GADD45G than any of the single agents.?Panobinostat plus SRT2183 in combination showed greater inhibition of c-Myc protein levels and phosphorylation of H2A.X, and increased acetylation of p53.?Furthermore, EMSA revealed that NF-κB binds directly to the GADD45G promoter, while STAT3 binds indirectly in complexes with NF-κB.?In addition, the binding of NF-κB/STAT3 complexes to the GADD45G promoter is inhibited following panobinostat, SRT501 or resveratrol treatment.?Moreover, the combination of panobinostat with SRT2183, SRT501 or resveratrol induces a greater binding repression than either agent alone[1].
Chemical Properties
Molecular Weight468.57
FormulaC27H24N4O2S
Cas No.1001908-89-9
SmilesO[C@@H]1CCN(Cc2csc3nc(cn23)-c2ccccc2NC(=O)c2ccc3ccccc3c2)C1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 240 mg/mL (512.2 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.67 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1342 mL10.6708 mL21.3415 mL106.7076 mL
5 mM0.4268 mL2.1342 mL4.2683 mL21.3415 mL
10 mM0.2134 mL1.0671 mL2.1342 mL10.6708 mL
20 mM0.1067 mL0.5335 mL1.0671 mL5.3354 mL
50 mM0.0427 mL0.2134 mL0.4268 mL2.1342 mL
100 mM0.0213 mL0.1067 mL0.2134 mL1.0671 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SRT-2183SRT2183SRT 2183SirtuinSIRT1InhibitorinhibitApoptosis
Related Tags: buy SRT 2183 | purchase SRT 2183 | SRT 2183 cost | order SRT 2183 | SRT 2183 chemical structure | SRT 2183 in vitro | SRT 2183 formula | SRT 2183 molecular weight
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