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Anti-FURIN Antibody (5P939)
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Catalog No. TMAC-01574
Alias PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme
Anti-FURIN Antibody (5P939) is a Rabbit antibody targeting FURIN. Anti-FURIN Antibody (5P939) can be used in ICC,IHC,WB.
Anti-FURIN Antibody (5P939)
Anti-FURIN Antibody (5P939)
😃Good
Catalog No. TMAC-01574Alias PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme
Anti-FURIN Antibody (5P939) is a Rabbit antibody targeting FURIN. Anti-FURIN Antibody (5P939) can be used in ICC,IHC,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-FURIN Antibody (5P939) is a Rabbit antibody targeting FURIN. Anti-FURIN Antibody (5P939) can be used in ICC,IHC,WB. |
| Synonyms | PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme |
| Ig Type | IgG |
| Clone | 5P939 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of Furin on different cell lysates using anti-Furin antibody at 1/500 dilution. Positive control: Lane 1: HepG2, Lane 2: Hela, Lane 3: Hela, Lane 4: MCF-7. 2. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Furin antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Furin antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-Furin antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Furin antibody. Counter stained with hematoxylin. |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50; ICC: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Furin (FUR, PACE, PCSK3, SPC1, Kex2p) is a calcium-dependent serine endoprotease that belongs to the subtilisin-like proprotein convertase family. The members of this family process latent precursor proteins into their biologically active products. Furin cleaves at paired basic amino acid processing sites within proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. Furin can directly cleave proMMP-2 within the trans-Golgi network leading to an inactive form of matrix metalloproteinase-2 (MMP-2). Furin is synthesized as an inactive zymogen that may minimize the occurrence of premature enzymatic activity that would lead to alternative protein activation or degradation. The inhibitory mechanism is based on the presence of an inactivating prosegment at the NH2 terminal of the Furin. After initial autocatalytic cleavage, the prosegment remains tightly associated until it reaches the trans-Golgi network where the dissociation of the prosegment and activation of furin occurs. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: human Furin aa 200-400 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 87 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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