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Quinidine methiodide

Name: Quinidine methiodide
Brand: TargetMol
SKU: T212770
Rating: 4.5 (1 reviews)

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Catalog No. T212770Cas No. 42982-87-6

Quinidine methiodide is a quaternized derivative of quinidine and a classical ion channel blocker. Unable to penetrate the blood-brain barrier, it prolongs action potential duration by exclusively blocking voltage-gated sodium and potassium channels on peripheral membranes, acting as a benchmark tool in neuromuscular and cardiovascular electrophysiology research.

Quinidine methiodide

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Purity: 99.78%

Catalog No. T212770Cas No. 42982-87-6

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Batch Information

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Purity:99.78%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Quinidine methiodide is a quaternized derivative of quinidine and a classical ion channel blocker. Unable to penetrate the blood-brain barrier, it prolongs action potential duration by exclusively blocking voltage-gated sodium and potassium channels on peripheral membranes, acting as a benchmark tool in neuromuscular and cardiovascular electrophysiology research.
In vitro	In electrophysiological experiments on squid giant axons, Quinidine methiodide was utilized to characterize internal sites of sodium channels. Studies revealed that the inhibitory effect of this quaternized metabolite is side-dependent, assisting researchers in deciphering the diffusion pathways and binding kinetics of quinidine-like molecules within the channel pore [1].

Chemical Properties

Molecular Weight	466.36
Formula	C₂₁H₂₇IN₂O₂
Cas No.	42982-87-6
Smiles	[C@@H](O)([C@@]1([N@+]2(C)C[C@H](C=C)[C@](C1)(CC2)[H])[H])C=3C4=C(C=CC(OC)=C4)N=CC3.[I-]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (171.54 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1443 mL	10.7213 mL	21.4427 mL	107.2133 mL
5 mM	0.4289 mL	2.1443 mL	4.2885 mL	21.4427 mL
10 mM	0.2144 mL	1.0721 mL	2.1443 mL	10.7213 mL
20 mM	0.1072 mL	0.5361 mL	1.0721 mL	5.3607 mL
50 mM	0.0429 mL	0.2144 mL	0.4289 mL	2.1443 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc