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Tyrphostin AG30
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Catalog No. T7101Cas No. 122520-79-0
Alias Tyrphostin AG30(AG30)
Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.
Tyrphostin AG30
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Purity: 99.02%
Catalog No. T7101Alias Tyrphostin AG30(AG30)Cas No. 122520-79-0
Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $39 | In Stock | In Stock | |
| 5 mg | $64 | In Stock | In Stock | |
| 10 mg | $80 | In Stock | In Stock | |
| 25 mg | $178 | In Stock | In Stock | |
| 50 mg | $322 | In Stock | In Stock | |
| 100 mg | $538 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.02%
Appearance:Solid
Color:White
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Product Introduction
Tyrphostin AG30 AI Summary
Tyrphostin AG30 is a multifaceted molecule known to inhibit the EGF-dependent autophosphorylation of the epidermal growth factor receptor kinase, with an IC50 value of 25,000 nM and a Ki value of 70,000 nM, highlighting its potential as a kinase inhibitor targeting the EGF receptor pathway. Additionally, it inhibits the epidermal growth factor receptor (EGFR) in human A431 cells with an IC50 of 30,000 nM and human recombinant Tdp1 with an IC50 value greater than 333,000 nM.
Moreover, Tyrphostin AG30 exhibits stimulatory effects on catechol-O-methyltransferase activity, enhancing the methylation of mouse heart cytosol proteins by 10.6 pmol/min and increasing pig recombinant catechol-O-methyltransferase activity by 3.67 pmol/min at a concentration of 100 µM after 2 hours.
The compound also has antinociceptive properties, as evidenced by a 31.8% inhibition of acetic acid-induced writhing in CD-1 mice at a 10 mg/kg dose and increased paw withdrawal latency in thermal-stimulus tests at 60 mg/kg dosage. Furthermore, Tyrphostin AG30 activates the TREK1 channel, increasing K+ current in human TREK1 channels expressed in HEK293 cells at 100 µM and in Xenopus oocytes at 20 µM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor. |
| Synonyms | Tyrphostin AG30(AG30) |
| Molecular Weight | 205.17 |
| Formula | C10H7NO4 |
| Cas No. | 122520-79-0 |
| Smiles | OC(=O)C(=C\c1ccc(O)c(O)c1)\C#N |
| Relative Density. | 1.559 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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