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Carbidopa monohydrate

Name: Carbidopa monohydrate
Brand: TargetMol
SKU: T2148
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2148Cas No. 38821-49-7

Alias S(-)-Carbidopa, Carbidopa Hydrate

Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.

Carbidopa monohydrate

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Purity: 98.30%

Catalog No. T2148Alias S(-)-Carbidopa, Carbidopa HydrateCas No. 38821-49-7

Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$48	-	In Stock
1 g	$71	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.30%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Carbidopa monohydrate AI Summary

Carbidopa monohydrate exhibits a broad spectrum of bioactivities and pharmacological properties. It shows antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 10000.0 nM to 12589.25 nM after 72 hours, as measured by SYBR green assays. It demonstrates uncompetitive inhibition of JMJD2E relative to alpha-ketoglutarate with a Ki value of 1980.0 nM, and inhibits Protein Tyrosine Kinase enzymes Fyn and LCK, with IC50 values of 3731.0 nM and 6795.0 nM, respectively. Furthermore, it inhibits the interaction between HIV1 integrase and LEDGF-75 with an IC50 value of 6540.0 nM. The compound also shows significant inhibition of sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells by 134.52% and 113.15%, respectively, at a 10 uM concentration. However, it has a moderate liver toxicity profile, presenting risks such as cholestasis, steatosis, and potentially acute liver toxicity, although conditions like cirrhosis and tumor formation have not been prominently observed. Testing against the FDA Liver Toxicity Knowledge Base Benchmark Dataset resulted in a DILI severity score of 4.0, though outcomes vary across other datasets. Carbidopa monohydrate influences a range of biological markers, including liver and kidney function, electrolyte balance, blood cell counts, blood proteins, glucose levels, and lipid metabolism. The compound's diverse bioactivities and high solubility in a 0.1 M phosphate buffer at pH 7.4 establish its potential as a candidate for various therapeutic investigations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.
Synonyms	S(-)-Carbidopa, Carbidopa Hydrate

Chemical Properties

Molecular Weight	244.24
Formula	C₁₀H₁₆N₂O₅
Cas No.	38821-49-7
Smiles	CC(CC1=CC=C(O)C(O)=C1)(NN)C(O)=O
Relative Density.	1.42 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.5 mg/mL (22.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0943 mL	20.4717 mL	40.9433 mL	204.7167 mL
5 mM	0.8189 mL	4.0943 mL	8.1887 mL	40.9433 mL
10 mM	0.4094 mL	2.0472 mL	4.0943 mL	20.4717 mL
20 mM	0.2047 mL	1.0236 mL	2.0472 mL	10.2358 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc