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Folinic acid calcium
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Catalog No. T0148Cas No. 1492-18-8
Alias Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate
Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
Folinic acid calcium
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Purity: 99.73%
Catalog No. T0148Alias Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinateCas No. 1492-18-8
Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $42 | In Stock | In Stock | |
| 200 mg | $55 | In Stock | In Stock | |
| 500 mg | $81 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.73%
Color:White to Yellow
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Product Introduction
Folinic acid calcium AI Summary
Folinic acid calcium exhibits significant growth inhibition activity across a diverse array of human tumor cell lines, including those from renal, non-small cell lung, leukemia, melanoma, ovarian, breast, central nervous system, and colon origins. The GI50 values range from 14,791.08 nM to 95,279.62 nM, highlighting its potential as an anti-cancer agent. Additionally, Folinic acid calcium strongly inhibits the uptake of sodium fluorescein in OATP1B1 and OATP1B3-transfected CHO cells by 80.81% and 90.54%, respectively, at a concentration of 10 µM. It also exhibits weak inhibitory effects on transport proteins such as BSEP, MRP2, MRP3, and MRP4, with IC50 values exceeding 133,000 nM.
In terms of safety, Folinic acid calcium does not induce liver toxicity, as indicated by a severity class index of 0.0 in drug-induced liver injury assays. Furthermore, it shows limited cytotoxicity against Vero E6 cells infected with SARS-CoV-2 at low MOI after 72 hours, and it demonstrates marginal inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells (-0.23%) and Vero-6 cells (0.03%) at 10 µM concentration after 48 hours. Additionally, the compound inhibits SARS-CoV-2 3CL-Pro protease by 30.5% at a concentration of 20 µM, as measured by FRET response from a peptide substrate. These characteristics suggest that Folinic acid calcium holds promise for further exploration as a multi-target therapeutic agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists. |
| Targets&IC50 | zcSHMT:30 μM, zmSHMT:70 μM |
| Synonyms | Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate |
| Molecular Weight | 511.51 |
| Formula | C20H21CaN7O7 |
| Cas No. | 1492-18-8 |
| Smiles | [Ca++].Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc2[nH]1 |
| Relative Density. | no data available |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: 9.8 mg/mL (19.16 mM), Sonication is recommended.  DMSO: Insoluble | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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