keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 849.00 |
Description | MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research. |
In vitro | MM 419447 demonstrates strong binding affinity for T84 cells, leading to a notable, concentration-dependent increase in intracellular cyclic guanosine-3',5'-monophosphate (cGMP)[1]. |
In vivo | Administration of MM 419447 at a dosage of 10 mg/kg orally to female Sprague-Dawley rats resulted in peak plasma concentration (Cmax) of 27 ng/mL, an area under the curve (AUC0-6) of up to 29.7 ng·h/mL, and a half-life (t1/2) of 0.33 hours, according to pharmacokinetic analysis[1]. |
Molecular Weight | 1363.55 |
Formula | C50H70N14O19S6 |
CAS No. | 1092457-78-7 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MM 419447 1092457-78-7 MM-419447 MM419447 inhibitor inhibit