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5-Aminouridine

Name: 5-Aminouridine
Brand: TargetMol
SKU: T13511
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13511Cas No. 2149-76-0

Alias 4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)

5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.

5-Aminouridine

🥰Excellent

Purity: 99.53%

Catalog No. T13511Alias 4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)Cas No. 2149-76-0

5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	-	In Stock
10 mg	$70	-	In Stock
25 mg	$114	-	In Stock
50 mg	$167	-	In Stock
100 mg	$248	-	In Stock
1 mL x 10 mM (in DMSO)	$58	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.53%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.
In vitro	5-Aminouridine inhibits the incorporation of carbamyl aspartate into pyrimidines of both RNA and DNA in rat lived and [32P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma[1]. 5-Aminouridine must exhibit a low potential to be oxidized by Os(bpy)33+. The modified nucleobase is inserted into the target DNA by direct synthesis using modified phosphoramidites[4].
In vivo	5-Aminouridine inhibits the incorporation of carbamoylaspartate into pyrimidines in living rat RNA and DNA, and the incorporation of [32P]phosphate into phospholipids and RNA nucleotides in rat liver slices and liver cancers [1].
Synonyms	4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)

Chemical Properties

Molecular Weight	259.22
Formula	C₉H₁₃N₃O₆
Cas No.	2149-76-0
Smiles	O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(N)=C2
Relative Density.	1.712 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (212.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8577 mL	19.2886 mL	38.5773 mL	192.8864 mL
5 mM	0.7715 mL	3.8577 mL	7.7155 mL	38.5773 mL
10 mM	0.3858 mL	1.9289 mL	3.8577 mL	19.2886 mL
20 mM	0.1929 mL	0.9644 mL	1.9289 mL	9.6443 mL
50 mM	0.0772 mL	0.3858 mL	0.7715 mL	3.8577 mL
100 mM	0.0386 mL	0.1929 mL	0.3858 mL	1.9289 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc