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5-Aminouridine

Name: 5-Aminouridine
Brand: TargetMol
SKU: T13511
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13511Cas No. 2149-76-0

Alias 4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)

5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.

5-Aminouridine

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Purity: 99.53%

Catalog No. T13511Alias 4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)Cas No. 2149-76-0

5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	-	In Stock
10 mg	$70	-	In Stock
25 mg	$114	-	In Stock
50 mg	$167	-	In Stock
100 mg	$248	-	In Stock
1 mL x 10 mM (in DMSO)	$58	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.53%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.
In vitro	5-Aminouridine inhibits the incorporation of carbamyl aspartate into pyrimidines of both RNA and DNA in rat lived and [32P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma[1]. 5-Aminouridine must exhibit a low potential to be oxidized by Os(bpy)33+. The modified nucleobase is inserted into the target DNA by direct synthesis using modified phosphoramidites[4].
In vivo	5-Aminouridine inhibits the incorporation of carbamoylaspartate into pyrimidines in living rat RNA and DNA, and the incorporation of [32P]phosphate into phospholipids and RNA nucleotides in rat liver slices and liver cancers [1].
Synonyms	4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)

Chemical Properties

Molecular Weight	259.22
Formula	C₉H₁₃N₃O₆
Cas No.	2149-76-0
Smiles	O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(N)=C2
Relative Density.	1.712 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (212.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8577 mL	19.2886 mL	38.5773 mL	192.8864 mL
5 mM	0.7715 mL	3.8577 mL	7.7155 mL	38.5773 mL
10 mM	0.3858 mL	1.9289 mL	3.8577 mL	19.2886 mL
20 mM	0.1929 mL	0.9644 mL	1.9289 mL	9.6443 mL
50 mM	0.0772 mL	0.3858 mL	0.7715 mL	3.8577 mL
100 mM	0.0386 mL	0.1929 mL	0.3858 mL	1.9289 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc