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MAO-B-IN-17

🥰Excellent
Catalog No. T60712Cas No. 2890188-81-3

MAO-B-IN-17 is a selective and potent monoamine oxidase B (MAO-B) inhibitor (IC50: 5.08 μM) used in the study of central nervous system disorders, including Parkinson's.

MAO-B-IN-17

MAO-B-IN-17

🥰Excellent
Purity: 99.41%
Catalog No. T60712Cas No. 2890188-81-3
MAO-B-IN-17 is a selective and potent monoamine oxidase B (MAO-B) inhibitor (IC50: 5.08 μM) used in the study of central nervous system disorders, including Parkinson's.
Pack SizePriceAvailabilityQuantity
5 mg$64In Stock
10 mg$105In Stock
25 mg$176In Stock
50 mg$262In Stock
100 mg$389In Stock
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Batch Information

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Purity:99.41%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
MAO-B-IN-17 is a selective and potent monoamine oxidase B (MAO-B) inhibitor (IC50: 5.08 μM) used in the study of central nervous system disorders, including Parkinson's.
Targets&IC50
MAO-A (human):>100 uM, MAO-B (human):5.08 uM
In vitro
Under the conditions of 10 μM concentration and 24 hours of exposure, MAO-B-IN-17 (Compound 4j) exhibits no cytotoxic effects on human neuroblastoma cells [1].
Chemical Properties
Molecular Weight305.32
FormulaC17H17F2NO2
Cas No.2890188-81-3
SmilesFC=1C=C(F)C=C(C1)N2CC3=CC(OC)=C(OC)C=C3CC2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (327.53 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2753 mL16.3763 mL32.7525 mL163.7626 mL
5 mM0.6551 mL3.2753 mL6.5505 mL32.7525 mL
10 mM0.3275 mL1.6376 mL3.2753 mL16.3763 mL
20 mM0.1638 mL0.8188 mL1.6376 mL8.1881 mL
50 mM0.0655 mL0.3275 mL0.6551 mL3.2753 mL
100 mM0.0328 mL0.1638 mL0.3275 mL1.6376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

hMAO-B
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