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Popular targets and compound library recommendations

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Endocrine and metabolic diseases, such as diabetes, thyroid disorders, adrenal diseases, and obesity, are caused by abnormalities in endocrine gland functions or disruptions in metabolic processes. The endocrine system, which includes the thyroid, pancreas, and adrenal glands, regulates numerous physiological functions in the body by secreting hormones. These hormones directly affect the body's metabolic processes, such as the synthesis and breakdown of substances. When this balance is disrupted, it can lead to abnormal energy metabolism, severely affecting patients' daily lives and health. In recent years, research has focused on developing new therapeutic drugs for these diseases, optimizing existing hormone replacement therapies, and gaining a deeper understanding of the impact of genetic and lifestyle factors on these diseases. The goal is to improve treatment efficacy, reduce drug side effects, and enhance patients' quality of life.

In this field, our company possesses a variety of inhibitors and activators targeting key objectives in the area of endocrine and metabolic diseases. We also offer several compound libraries specifically for endocrine and metabolic diseases, such as endocrinology-hormone compound library, anti-obesity compound library, anti-diabetic compound library, and anti-metabolism disease compound library. These resources support the development of drugs for the treatment of various endocrine and metabolic diseases, including diabetes, thyroid disorders, and more.

Popular targets recommendations

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
193 Products
TargetMol | Compound Library | Targets | Pathway
Liver X Receptor
The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands, they were subsequently deorphanized.Two isoforms of LXR have been identified and are referred to as LXRα and LXRβ.
25 Products
TargetMol | Compound Library | Targets | Pathway
Thyroid hormone receptor(THR)
The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone.TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation. These receptors also have non-genomic effects that lead to second messenger activation, and corresponding cellular response.
34 Products
TargetMol | Compound Library | Targets | Pathway
Glucagon Receptor
The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene.
62 Products
TargetMol | Compound Library | Targets | Pathway
A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, which are distinguished by the type of reaction which they catalyze.
99 Products
TargetMol | Compound Library | Targets | Pathway
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent. It is used by all forms of cellular life.NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety. This extra phosphate is added by NAD+ kinase and removed by NADP+ phosphatase.
34 Products
TargetMol | Compound Library | Targets | Pathway
G-protein coupled receptors (GPRs) are a family of seven-transmembrane receptors, which play an important role in the response to peptide hormones, neurotransmitters, and free fatty acids.
135 Products
TargetMol | Compound Library | Targets | Pathway
Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.
96 Products
TargetMol | Compound Library | Targets | Pathway
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term 'P450' is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
221 Products
TargetMol | Compound Library | Targets | Pathway
Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the 'hunger hormone'. The role of GHS-R is thought to be in regulating energy homeostasis and body weight. In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra. Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even in the heart.
19 Products
TargetMol | Compound Library | Targets | Pathway
The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor.
55 Products
TargetMol | Compound Library | Targets | Pathway
A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
187 Products
TargetMol | Compound Library | Targets | Pathway

Popular compound libraries recommendations

Endocrinology-Hormone Compound Library
L2400813 Compounds
A unique collection of 813 compounds targeting endocrine system for high throughput screening (HTS) and high content screening (HCS) for new drugs;
TargetMol | Literature Listed in literature
TargetMol | Compound Library | Targets | Pathway
Anti-Obesity Compound Library
L71002286 Compounds
A unique collection of 2286 anti-obesity compounds for high throughput and high content screening;
TargetMol | Literature Listed in literature
TargetMol | Compound Library | Targets | Pathway
Anti-Diabetic Compound Library
L1900690 Compounds
A unique collection of 690 diabetes related compounds;
TargetMol | Literature Listed in literature
TargetMol | Compound Library | Targets | Pathway
Anti-Metabolism Disease Compound Library
L52001558 Compounds
A unique collection of 1558 metabolism diseases related compounds for high throughput screening (HTS) and high content screening (HCS);
TargetMol | Literature Listed in literature
TargetMol | Compound Library | Targets | Pathway
Anti-Hypertension Compound Library
L7110719 Compounds
719 hypertension-related small molecules for high-throughput and high-content screening.
TargetMol | Literature Listed in literature
TargetMol | Compound Library | Targets | Pathway
Serotonin Receptor-Targeted Compound Library
L2800275 Compounds
A unique collection of 275 compounds targeting serotonin receptors for high throughput screening and high content screening;
TargetMol | Literature Listed in literature
TargetMol | Compound Library | Targets | Pathway