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Anti-Epac1 Antibody (3T871) is a Rabbit antibody targeting Epac1. Anti-Epac1 Antibody (3T871) can be used in WB,IHC,IP,ICC/IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $298 | 7-10 days | |
100 μL | $497 | 7-10 days |
Description | Anti-Epac1 Antibody (3T871) is a Rabbit antibody targeting Epac1. Anti-Epac1 Antibody (3T871) can be used in WB,IHC,IP,ICC/IF. |
Synonyms | RAPGEF3, Rap1 guanine nucleotide exchange factor directly activated by cAMP, RAP guanine nucleotide exchange factor 3, Rap guanine nucleotide exchange factor (GEF) 3, RAP guanine nucleotide exchange factor, MGC21410, Exchange protein directly activated by cAMP 1, Exchange factor directly activated by cAMP 1, EPAC1, Epac 1, EPAC, EPA1, CGEF1, CGEF 1, CAMPGEFI, cAMP regulated guanine nucleotide exchange factor I, CAMP GEFI, bcm910 |
Ig Type | IgG |
Clone | 3T871 |
Reactivity | Human,Mouse |
Verified Activity | 1. Western blot analysis of Epac1 on mouse kidney tissue lysate using anti-Epac1 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-Epac1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti-Epac1 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Epac1 antibody. Counter stained with hematoxylin. |
Application | |
Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:10-50; IP: 1:10-50 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | Recombinant Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | 3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac (Epac1, cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the Ras family GTPases Rap 1 and Rap 2 by promoting GTP binding in a cAMP-dependent manner. Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission. The human Epac gene maps to chromosome 12q13.11 with transcript being abundant in the kidney and heart. In situ hybridization indicates expression of Epac in adult rat brain and selective expression in neonatal brain, including septum and thalamus. |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein |
Uniprot ID |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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