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PEAQX tetrasodium hydrate

Name: PEAQX tetrasodium hydrate
Brand: TargetMol
SKU: T16451
Price: 1070 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16451

Alias PEAQX tetrasodium hydrate (459836-30-7 free base), PEAQX tetrasodium hydrate, NVP-AAM077 tetrasodium hydrate

PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively.

PEAQX tetrasodium hydrate

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Purity: 99%

Catalog No. T16451Alias PEAQX tetrasodium hydrate (459836-30-7 free base), PEAQX tetrasodium hydrate, NVP-AAM077 tetrasodium hydrate

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$1,070	-	In Stock

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Purity:99%

Appearance:Oil

Color:White

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Product Introduction

Bioactivity

Description	PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively.
Targets&IC50	NMDAR 1A/2B (human):29600 nM, NMDAR 1A/2A (human):270 nM
In vitro	PEAQX has a high binding affinity for NMDA receptors (IC50=8 nM), and a functional preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over 1A/2B receptors (IC50=29,600 nM).[1]
In vivo	PEAQX is practically inactive in Xenopus oocytes expressing hNMDA 1A/2B receptors, displays an ED50 value of 23 mg/kg in the MES test [1]. Sprague-Dawley rats were treated on PN7, PN9, and PN11 with PCP (10 mg/kg), PEAQX (NR2A-preferring antagonist; 10, 20, or 40 mg/kg), or ifenprodil (selective NR2B antagonist; 1, 5, or 10 mg/kg) and sacrificed for measurement of caspase-3 activity (an index of apoptosis) or allowed to age and tested for locomotor sensitization to PCP challenge on PN28-PN35. PCP or PEAQX on PN7, PN9, and PN11 markedly elevated caspase-3 activity in the cortex; ifenprodil showed no effect. Striatal apoptosis was evident only after subchronic treatment with a high dose of PEAQX (20 mg/kg). Animals treated with PCP or PEAQX on PN7, PN9, and PN11 showed a sensitized locomotor response to the PCP challenge on PN28-PN35.[2]
Synonyms	PEAQX tetrasodium hydrate (459836-30-7 free base), PEAQX tetrasodium hydrate, NVP-AAM077 tetrasodium hydrate

Chemical Properties

Molecular Weight	560.15
Formula	C₁₇H₁₅BrN₃Na₄O₆P
Smiles	[O-]P([O-])(C(C1=CC=CC2=C1N=C(C([O-])=N2)[O-])N[C@H](C3=CC=C(C=C3)Br)C)=O.[H]O[H].[Na+].[Na+].[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 22.9 mg/mL (40.88 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.7852 mL	8.9262 mL	17.8524 mL	89.2618 mL
5 mM	0.3570 mL	1.7852 mL	3.5705 mL	17.8524 mL
10 mM	0.1785 mL	0.8926 mL	1.7852 mL	8.9262 mL
20 mM	0.0893 mL	0.4463 mL	0.8926 mL	4.4631 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc