IL-23R Protein, Human, Recombinant (aa 24-355, His)

Catalog No. TMPK-00353 Copy Product Info

IL-23R Protein, Human, Recombinant (aa 24-355, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.15 kDa and the accession number is Q5VWK5-1.

IL-23R Protein, Human, Recombinant (aa 24-355, His)

Catalog No. TMPK-00353

Copy Product Info

IL-23R Protein, Human, Recombinant (aa 24-355, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.15 kDa and the accession number is Q5VWK5-1.

Pack Size	Price	USA Stock	Global Stock
5 μg	$58	7-10 days	7-10 days
10 μg	$92	7-10 days	7-10 days
20 μg	$148	7-10 days	7-10 days
50 μg	$289	7-10 days	7-10 days
100 μg	$487	7-10 days	7-10 days
200 μg	$883	7-10 days	7-10 days
500 μg	$1,950	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	1. Immobilized Human IL-23R, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 0.87μg/ml determined by ELISA (QC Test). 2. Human IL-23R, His Tag immobilized on CM5 Chip can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 5.72 nM as determined in SPR assay.
Description	IL-23R Protein, Human, Recombinant (aa 24-355, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.15 kDa and the accession number is Q5VWK5-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q5VWK5-1
Synonyms	IL-23 receptor,IL-23 R,IBD17
Construction	Gly24-Gly355
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	39.15 kDa (predicted). Due to glycosylation, the protein migrates to 60-75 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.