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Protocatechualdehyde

Name: Protocatechualdehyde
Brand: TargetMol
SKU: T3018
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3018Cas No. 139-85-5

Alias Rancinamycin IV, Protocatechuic aldehyde, Catechaldehyde, 3,4-Dihydroxybenzaldehyde

Protocatechualdehyde (3,4-Dihydroxybenzaldehyde), a natural polyphenol compound derived from radix Salviae Miltiorrhizae roots, exhibits diverse biological activities and finds extensive medicinal applications as an antioxidant, anti-aging, antibacterial, and anti-inflammatory agent.

Protocatechualdehyde

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Purity: 99.66%

Catalog No. T3018Alias Rancinamycin IV, Protocatechuic aldehyde, Catechaldehyde, 3,4-DihydroxybenzaldehydeCas No. 139-85-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.66%

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Protocatechualdehyde AI Summary

Protocatechualdehyde exhibits a diverse range of bioactivities, making it a promising candidate for various therapeutic applications. It shows significant antioxidant properties by scavenging ABTS radicals (IC50 = 5000 nM), superoxide anion radicals (IC50 = 25300 nM), and DPPH radicals (IC50 = 29400 nM). The compound demonstrates cytotoxic activity against human DLD1 cells with an IC50 of 70000 nM and possesses antitumor initiating activity in human Chang cells. It also exhibits bioactivity by inhibiting theophylline-stimulated melanogenesis in mouse B16-4A5 cells (IC50 = 17000 nM). Additionally, Protocatechualdehyde inhibits mushroom tyrosinase activity, with significant potential for skin-lightening applications, and shows antineuroinflammatory effects by reducing nitric oxide production in mouse N9 and BV2 cells. Protocatechualdehyde's diverse enzyme inhibition profiles include Pieris rapae phenoloxidase (multiple IC50 values), human Jumonji Domain Containing 2E, Bacillus subtilis Sfp phosphopantetheinyl transferase, and others. It demonstrates antiviral activity against the Hepatitis B virus by reducing DNA production and antigen secretion in HepG2.2.15 cells, and it shows inhibition of the MERS-CoV papain-like protease (IC50 = 239000 nM). Moreover, the compound has demonstrated protective activities against venom-induced mortality in mice, moderate inhibition of Streptococcus mutans enzymes, and bioactivity against nematodes such as Meloidogyne incognita. Protocatechualdehyde also promotes osteoblast activity while inhibiting osteoclast differentiation in mouse cells and exhibits moderate COX-2 inhibition (IC50 = 19700 nM). These multifaceted activities highlight Protocatechualdehyde's potential as an antioxidant, anticancer, antiviral, anti-inflammatory, and enzyme inhibitory agent, warranting further investigation for therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Protocatechualdehyde (3,4-Dihydroxybenzaldehyde), a natural polyphenol compound derived from radix Salviae Miltiorrhizae roots, exhibits diverse biological activities and finds extensive medicinal applications as an antioxidant, anti-aging, antibacterial, and anti-inflammatory agent.
Synonyms	Rancinamycin IV, Protocatechuic aldehyde, Catechaldehyde, 3,4-Dihydroxybenzaldehyde

Chemical Properties

Molecular Weight	138.12
Formula	C₇H₆O₃
Cas No.	139-85-5
Smiles	OC1=C(O)C=C(C=O)C=C1
Relative Density.	1.409g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1810.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2401 mL	36.2004 mL	72.4008 mL	362.0041 mL
5 mM	1.4480 mL	7.2401 mL	14.4802 mL	72.4008 mL
10 mM	0.7240 mL	3.6200 mL	7.2401 mL	36.2004 mL
20 mM	0.3620 mL	1.8100 mL	3.6200 mL	18.1002 mL
50 mM	0.1448 mL	0.7240 mL	1.4480 mL	7.2401 mL
100 mM	0.0724 mL	0.3620 mL	0.7240 mL	3.6200 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc