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KL001

Name: KL001
Brand: TargetMol
SKU: T22891
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22891Cas No. 309928-48-1

Alias KL-001, KL 001

KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.

KL001

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Purity: 99.22%

Catalog No. T22891Alias KL-001, KL 001Cas No. 309928-48-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$116	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$293	In Stock	In Stock
100 mg	$438	In Stock	In Stock
500 mg	$983	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.22%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

KL001 AI Summary

KL001 exhibits a diverse range of bioactivities across various assays and targets. It has been identified as having agonist activity for the Thyroid Stimulating Hormone Receptor and inhibitory activity against Cruzain and several other targets, including Influenza NS1 Protein, JMJD2A-Tudor Domain, Nrf2, GCN5L2, Histone Lysine Methyltransferase G9a, BAZ2B, Thioredoxin Reductase 1, malarial parasite plastid, Lassa Virus, Marburg Virus, GLP-1 Receptor, Pin1, and USP1/UAF1 complex. Additionally, it has shown modulation of lipid storage in Drosophila S3 Cells and promotion of Anthrax Lethal Toxin internalization. In human U2OS cells harboring Per2-dLuc luciferase reporter gene, it demonstrated bioactivity in reducing PER2 amplitude effect with an EC50 of 870.0 nM, suggesting potential in circadian rhythm regulation. It also shows modulation activity at CRY2/PER2 with an EC50 of 870.0 nM and demonstrated a stronger activity on Cry1/Cry2 with an EC50 of 340.0 nM in the same cell type. In HEK293 cells, it showed an EC50 of 9410.0 nM for modulating C-terminal FLAG3-tagged CRY1. For its antiviral activity, KL001 inhibited SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, though with varying effectiveness, and exhibited moderate inhibition of the SARS-CoV-2 3CL-Pro protease at 20µM. Additionally, it showed mild inhibitory activity against human HDAC6 in enzymatic assays. These activities highlight the compound's potential for therapeutic applications in various diseases, including viral infections and circadian rhythm disorders..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
Synonyms	KL-001, KL 001

Chemical Properties

Molecular Weight	398.48
Formula	C₂₁H₂₂N₂O₄S
Cas No.	309928-48-1
Smiles	CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65.8 mg/mL (165.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5095 mL	12.5477 mL	25.0954 mL	125.4768 mL
5 mM	0.5019 mL	2.5095 mL	5.0191 mL	25.0954 mL
10 mM	0.2510 mL	1.2548 mL	2.5095 mL	12.5477 mL
20 mM	0.1255 mL	0.6274 mL	1.2548 mL	6.2738 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5095 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc