Shopping Cart

Your shopping cart is currently empty

VER-50589

Name: VER-50589
Brand: TargetMol
SKU: T2258
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T2258Cas No. 747413-08-7

Alias VER50589

VER-50589 is a potent HSP90 inhibitor.

VER-50589

😃Good

Purity: 99.96%

Catalog No. T2258Alias VER50589Cas No. 747413-08-7

VER-50589 is a potent HSP90 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$162	In Stock	In Stock
25 mg	$278	In Stock	In Stock
50 mg	$426	In Stock	In Stock
100 mg	$619	In Stock	In Stock
200 mg	$875	-	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.96%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VER-50589 is a potent HSP90 inhibitor.
Targets&IC50	HSP90 β:21 nM
In vitro	The induction of HSP72 and HSP27 by VER-50589 was accompanied by depletion of client proteins (including C-RAF, B-RAF, and survivin) and the protein arginine methyltransferase PRMT5, which further led to cell cycle arrest and apoptosis.VER-50589 inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 with an IC50 of 143 nM, and inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 in vitro with an IC50 of 143 nM. and produced antiproliferative activity in a panel of human cancer cell lines and non-tumorigenic cells in vitro.
In vivo	The induction of HSP72 and HSP27 by VER-50589 was accompanied by depletion of client proteins (including C-RAF, B-RAF, and survivin) and the protein arginine methyltransferase PRMT5, which further led to cell cycle arrest and apoptosis.VER-50589 inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 with an IC50 of 143 nM, and inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 in vitro with an IC50 of 143 nM. and produced antiproliferative activity in a panel of human cancer cell lines and non-tumorigenic cells in vitro.
Kinase Assay	Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe.
Cell Research	Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method.(Only for Reference)
Synonyms	VER50589

Chemical Properties

Molecular Weight	388.8
Formula	C₁₉H₁₇ClN₂O₅
Cas No.	747413-08-7
Smiles	CCNC(=O)c1noc(c1-c1ccc(OC)cc1)-c1cc(Cl)c(O)cc1O
Relative Density.	1.360 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 71 mg/mL (182.61 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (182.61 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5720 mL	12.8601 mL	25.7202 mL	128.6008 mL
5 mM	0.5144 mL	2.5720 mL	5.1440 mL	25.7202 mL
10 mM	0.2572 mL	1.2860 mL	2.5720 mL	12.8601 mL
20 mM	0.1286 mL	0.6430 mL	1.2860 mL	6.4300 mL
50 mM	0.0514 mL	0.2572 mL	0.5144 mL	2.5720 mL
100 mM	0.0257 mL	0.1286 mL	0.2572 mL	1.2860 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc