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Zinc pyrithione

Name: Zinc pyrithione
Brand: TargetMol
SKU: T0502
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0502Cas No. 13463-41-7

Alias OM-1563

Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.

Zinc pyrithione

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Purity: 99.70%

Catalog No. T0502Alias OM-1563Cas No. 13463-41-7

Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$35	In Stock	In Stock
1 g	$47	In Stock	In Stock
5 g	$77	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.70%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.
In vitro	In exposed mussel tissues, Zinc pyrithione accumulates rapidly, with the rate of accumulation being proportional to both exposure concentration and time. Despite a 7-day LC50 (lethal concentration for 50% of the population) of 8.27 μM in relatively higher concentrations of Zinc pyrithione, this indicates a potential threat to coastal ecosystems and marine life, necessitating further investigation into its sub-lethal biological effects.
In vivo	As a specific synthetic potentiator, Zinc pyrithione activates homotypic and heterotypic M channels by inducing a resting potential. It is considered a zinc complex. The Pyrithione ligand (formally a monoanion) chelates with Zn2+ through oxygen and iron-sulfur centers. In the crystalline state, Zinc pyrithione exists as a centrosymmetric dimer, with each zinc atom coordinated to two sulfur and three oxygen centers. However, in solution, the dimers dissociate through the cleavage of zinc-oxygen bonds. Although Zinc pyrithione is a dimer, its activity causing cytoplasmic membrane depolarization may originate from the monomer, with an effective concentration for half-maximum effect (K1/2) of approximately 0.3 mM.
Synonyms	OM-1563

Chemical Properties

Molecular Weight	317.71
Formula	C₁₀H₈N₂O₂S₂Zn
Cas No.	13463-41-7
Smiles	[O-]1N2C=CC=CC2=[S][Zn+2]13[O-]N4C=CC=CC4=[S]3
Relative Density.	1.782 g/cm3 at 25℃

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 33 mg/mL (103.87 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (6.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1475 mL	15.7376 mL	31.4752 mL	157.3762 mL
5 mM	0.6295 mL	3.1475 mL	6.2950 mL	31.4752 mL
10 mM	0.3148 mL	1.5738 mL	3.1475 mL	15.7376 mL
20 mM	0.1574 mL	0.7869 mL	1.5738 mL	7.8688 mL
50 mM	0.0630 mL	0.3148 mL	0.6295 mL	3.1475 mL
100 mM	0.0315 mL	0.1574 mL	0.3148 mL	1.5738 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc