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IL12RB1 Protein, Human, Recombinant (hFc)
(Synonyms: interleukin-12 receptor β-1 chain, interleukin-12 receptor subunit β-1, interleukin-12 receptor subunit beta-1, interleukin-12 receptor beta-1 chain, IL-12R-β-1, IL-12R-β1, IL-12R-beta-1, IL-12R-BETA1, IL-12RB1, IL12RB1, IL12RB, IL-12R subunit β-1, IL-12R subunit beta-1, IL12R, IL-12 receptor β component, IL-12 receptor subunit β-1, IL-12 receptor subunit beta-1, IL-12 receptor beta component, CD212 antigen, CD212) Copy Product InfoSynonyms: interleukin-12 receptor β-1 chain, interleukin-12 receptor subunit β-1, interleukin-12 receptor subunit beta-1, interleukin-12 receptor beta-1 chain, IL-12R-β-1, IL-12R-β1, IL-12R-beta-1, IL-12R-BETA1, IL-12RB1, IL12RB1, IL12RB, IL-12R subunit β-1, IL-12R subunit beta-1, IL12R, IL-12 receptor β component, IL-12 receptor subunit β-1, IL-12 receptor subunit beta-1, IL-12 receptor beta component, CD212 antigen, CD212
Catalog No. TMPJ-00363 Copy Product Info
Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $46 | 7-10 days | 7-10 days | |
| 10 μg | $72 | 7-10 days | 7-10 days | |
| 20 μg | $115 | 7-10 days | 7-10 days | |
| 50 μg | $222 | 7-10 days | 7-10 days | |
| 100 μg | $418 | 7-10 days | 7-10 days | |
| 200 μg | $783 | 7-10 days | 7-10 days | |
| 500 μg | $1,900 | 7-10 days | 7-10 days | |
| 1 mg | $2,730 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc (IgG1) |
| Accession Number | P42701-1 |
| Amino Acid | Cys24-Glu540 |
| Construction | Cys24-Glu540 |
| Protein Purity | > 95% as determined by Bis-Tris PAGE |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | interleukin-12 receptor β-1 chain, interleukin-12 receptor subunit β-1, interleukin-12 receptor subunit beta-1, interleukin-12 receptor beta-1 chain, IL-12R-β-1, IL-12R-β1, IL-12R-beta-1, IL-12R-BETA1, IL-12RB1, IL12RB1, IL12RB, IL-12R subunit β-1, IL-12R subunit beta-1, IL12R, IL-12 receptor β component, IL-12 receptor subunit β-1, IL-12 receptor subunit beta-1, IL-12 receptor beta component, CD212 antigen, CD212 |
| Research Background |
| Molecular Weight | 83.85 kDa (predicted); 95-115 kDa (reducing condition, due to glycosylation) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: IL12RB1 Protein, Human, Recombinant (hFc) chemical structure | IL12RB1 Protein, Human, Recombinant (hFc) molecular weight
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