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Siramesine hydrochloride

Name: Siramesine hydrochloride
Brand: TargetMol
SKU: T1885
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1885Cas No. 224177-60-0

Alias Lu 28-179 hydrochloride

Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.

Siramesine hydrochloride

🥰Excellent

Purity: 99.75%

Catalog No. T1885Alias Lu 28-179 hydrochlorideCas No. 224177-60-0

Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.

Pack Size	Price	Availability
1 mg	$55	In Stock
2 mg	$80	In Stock
5 mg	$113	In Stock
10 mg	$183	In Stock
25 mg	$372	In Stock
50 mg	$556	In Stock
100 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Batch Information

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Purity:99.75%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.
Synonyms	Lu 28-179 hydrochloride

Chemical Properties

Molecular Weight	491.04
Formula	C₃₀H₃₂ClFN₂O
Cas No.	224177-60-0
Smiles	Cl.Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0365 mL	10.1825 mL	20.3649 mL	101.8247 mL
5 mM	0.4073 mL	2.0365 mL	4.0730 mL	20.3649 mL
10 mM	0.2036 mL	1.0182 mL	2.0365 mL	10.1825 mL
20 mM	0.1018 mL	0.5091 mL	1.0182 mL	5.0912 mL
50 mM	0.0407 mL	0.2036 mL	0.4073 mL	2.0365 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc