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CK37
(Synonyms: CK-37) Copy Product Info
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Synonyms: CK-37
Catalog No. T71648 Copy Product Info
Purity: 98.39%
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CK37 is a specific inhibitor of hCKα (hChoKα, human choline kinase-α) which inhibits the enzymatic activity of hCKα by competitively binding to its choline-binding domain. CK37 impairs HCV RNA replication and viral protein expression, and disrupts the accumulation of PI4P in HCV-infected cells.
Cas No. 1001478-90-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $113 | - | In Stock | |
| 5 mg | $276 | - | In Stock | |
| 10 mg | $397 | - | In Stock | |
| 25 mg | $673 | - | In Stock | |
| 50 mg | $948 | - | In Stock | |
| 100 mg | $1,270 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.39%
Appearance:Solid
Color:White
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Product Information
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Chemical Properties
Storage & Solubility Information
| Description | CK37 is a specific inhibitor of hCKα (hChoKα, human choline kinase-α) which inhibits the enzymatic activity of hCKα by competitively binding to its choline-binding domain. CK37 impairs HCV RNA replication and viral protein expression, and disrupts the accumulation of PI4P in HCV-infected cells. |
| In vitro | CK37 (100 μM, 24 h) decreases NS5A expression detected by Western blot analysis and impaires PI4P accumulation in HCV-infected cells. [1]
CK37 (100 μM, 24 h) inhibits the colocalization of NS5B with HA-PI4KIIIα and the colocalization of these proteins on the ER[1]. CK37 (3 μM, 48 h) downregulates MYC expression in Jurkat cells using immunofluorescence assay[2]. |
| In vivo | CK37 (4 mg/kg per day; once daily; 8 days) remarkably retards tumor growth, suppressed Ras-AKT/ERK signaling and increases lysophosphatidylcholine levels in a T-lymphoma xenograft murine model mice[2]. |
| Synonyms | CK-37 |
| Molecular Weight | 366.48 |
| Formula | C20H22N4OS |
| Cas No. | 1001478-90-5 |
| Smiles | O=C(NC=1C=C(C=C(C1)C)C)CSC2=NN=C(N2)C=3C=CC(=CC3)CC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: CK37 chemical structure | CK37 in vivo | CK37 in vitro | CK37 formula | CK37 molecular weight
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