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(Rac)-Sabcomeline HCl

Catalog No. T68135L CAS 133642-67-8

Synonyms: sabcomeline HCl(149156-36-5 Free base)

Sabcomeline HCl is an M1 receptor agonist that can be used to study Alzheimer's disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(Rac)-Sabcomeline HCl Chemical Structure

(Rac)-Sabcomeline HCl, CAS 133642-67-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 430.00
10 mg	In stock	$ 636.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,360.00
100 mg	In stock	$ 1,830.00

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Purity: 99.03%

Biological Description

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Description

Sabcomeline HCl is an M1 receptor agonist that can be used to study Alzheimer's disease.

In vivo

Sabcomeline HCl dose-dependently increased dopamine efflux in the medial prefrontal cortex but only a high dose of sabcomeline HCl (1 mg/kg; s.c.; rats) increased that in the nucleus accumbens. According to the analysis of net-AUC (area under the curve) values of acetylcholine and dopamine levels, the rank order of ability of these drugs to increase acetylcholine or dopamine levels is sabcomeline HCl>xanomeline approximately AC260584>N-desmethylclozapine.[5]

Synonyms	sabcomeline HCl(149156-36-5 Free base)
Molecular Weight	229.71
Formula	C10H16ClN3O
CAS No.	133642-67-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hosoi R, et al. Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain. Ann Nucl Med. 2003;17(2):123-130. 2. Hatcher JP, et al. Sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, reverses delay-induced deficits in the T-maze. Psychopharmacology (Berl). 1998;138(3-4):275-282. 3. Hosoi R, et al. Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain. Ann Nucl Med. 2003;17(2):123-130. 4. Watson JM, et al. In vitro characterisation of the muscarinic receptor partial agonist, sabcomeline, in rat cortical and heart membranes. Eur J Pharmacol. 1999;370(1):69-77. 5. Li Z, et al. Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine. Eur J Pharmacol. 2008;596(1-3):89-97.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

(Rac)-Sabcomeline HCl 133642-67-8 Neuroscience AChR sabcomeline HCl(149156-36-5 Free base) Sabcomeline HCl inhibitor inhibit

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