Shopping Cart

Your shopping cart is currently empty

(Rac)-Sabcomeline HCl

Name: (Rac)-Sabcomeline HCl
Brand: TargetMol
SKU: T68135L
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T68135LCas No. 133642-67-8

Alias sabcomeline HCl(149156-36-5 Free base)

Sabcomeline HCl is an M1 receptor agonist that can be used to study Alzheimer's disease.

(Rac)-Sabcomeline HCl

😃Good

Purity: 99.58%

Catalog No. T68135LAlias sabcomeline HCl(149156-36-5 Free base)Cas No. 133642-67-8

Sabcomeline HCl is an M1 receptor agonist that can be used to study Alzheimer's disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	-	In Stock
5 mg	$430	-	In Stock
10 mg	$636	-	In Stock
25 mg	$987	-	In Stock
50 mg	$1,360	-	In Stock
100 mg	$1,830	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.58%

Appearance:Oil

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sabcomeline HCl is an M1 receptor agonist that can be used to study Alzheimer's disease.
In vivo	Sabcomeline HCl dose-dependently increased dopamine efflux in the medial prefrontal cortex but only a high dose of sabcomeline HCl (1 mg/kg; s.c.; rats) increased that in the nucleus accumbens. According to the analysis of net-AUC (area under the curve) values of acetylcholine and dopamine levels, the rank order of ability of these drugs to increase acetylcholine or dopamine levels is sabcomeline HCl>xanomeline approximately AC260584>N-desmethylclozapine.[5]
Synonyms	sabcomeline HCl(149156-36-5 Free base)

Chemical Properties

Molecular Weight	229.71
Formula	C₁₀H₁₆ClN₃O
Cas No.	133642-67-8
Smiles	Cl.N#CC(=NOC)C1CN2CCC1CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (217.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3533 mL	21.7666 mL	43.5332 mL	217.6658 mL
5 mM	0.8707 mL	4.3533 mL	8.7066 mL	43.5332 mL
10 mM	0.4353 mL	2.1767 mL	4.3533 mL	21.7666 mL
20 mM	0.2177 mL	1.0883 mL	2.1767 mL	10.8833 mL
50 mM	0.0871 mL	0.4353 mL	0.8707 mL	4.3533 mL
100 mM	0.0435 mL	0.2177 mL	0.4353 mL	2.1767 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc