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p38-α MAPK-IN-1

Name: p38-α MAPK-IN-1
Brand: TargetMol
SKU: T12347
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12347Cas No. 443913-15-3

p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with an IC50 of 2300 nM in the EFC displacement assay and 5500 nM in the HTRF assay.

p38-α MAPK-IN-1

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Purity: 99.93%

Catalog No. T12347Cas No. 443913-15-3

p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with an IC50 of 2300 nM in the EFC displacement assay and 5500 nM in the HTRF assay.

Pack Size	Price	Availability
1 mg	$81	In Stock
5 mg	$189	In Stock
10 mg	$296	In Stock
25 mg	$547	In Stock
50 mg	$818	In Stock
100 mg	$1,230	In Stock
200 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Purity:99.93%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with an IC50 of 2300 nM in the EFC displacement assay and 5500 nM in the HTRF assay.
Targets&IC50	p38α:2300 nM in EFC assay, p38α:5500 nM in HTRF assay
In vitro	p38-α MAPK-IN-1 is a MAPK14 (p38-α)?inhibitor(IC50 of 2300 nM, in EFC displacement assay, and 5500 nM in HTRF assay)[1].

Chemical Properties

Molecular Weight	477.6
Formula	C₂₇H₃₅N₅O₃
Cas No.	443913-15-3
Smiles	Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)cc1)C(C)(C)C
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (209.38 mM), Sonication is recommended.

H2O: insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0938 mL	10.4690 mL	20.9380 mL	104.6901 mL
5 mM	0.4188 mL	2.0938 mL	4.1876 mL	20.9380 mL
10 mM	0.2094 mL	1.0469 mL	2.0938 mL	10.4690 mL
20 mM	0.1047 mL	0.5235 mL	1.0469 mL	5.2345 mL
50 mM	0.0419 mL	0.2094 mL	0.4188 mL	2.0938 mL
100 mM	0.0209 mL	0.1047 mL	0.2094 mL	1.0469 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc