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p38-α MAPK-IN-1

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Catalog No. T12347Cas No. 443913-15-3

p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with an IC50 of 2300 nM in the EFC displacement assay and 5500 nM in the HTRF assay.

p38-α MAPK-IN-1

p38-α MAPK-IN-1

😃Good
Purity: 99.93%
Catalog No. T12347Cas No. 443913-15-3
p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with an IC50 of 2300 nM in the EFC displacement assay and 5500 nM in the HTRF assay.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$81In StockIn Stock
5 mg$189In StockIn Stock
10 mg$296In StockIn Stock
25 mg$547In StockIn Stock
50 mg$818In StockIn Stock
100 mg$1,230In StockIn Stock
200 mg$1,650-In Stock
1 mL x 10 mM (in DMSO)$198In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.93%
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Product Introduction

Bioactivity
Description
p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with an IC50 of 2300 nM in the EFC displacement assay and 5500 nM in the HTRF assay.
Targets&IC50
p38α:5500 nM in HTRF assay, p38α:2300 nM in EFC assay
In vitro
p38-α MAPK-IN-1 is a MAPK14 (p38-α)?inhibitor(IC50 of 2300 nM, in EFC displacement assay, and 5500 nM in HTRF assay)[1].
Chemical Properties
Molecular Weight477.6
FormulaC27H35N5O3
Cas No.443913-15-3
SmilesCc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)cc1)C(C)(C)C
Relative Density.1.19 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (209.38 mM), Sonication is recommended.
H2O: insoluble
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.38 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0938 mL10.4690 mL20.9380 mL104.6901 mL
5 mM0.4188 mL2.0938 mL4.1876 mL20.9380 mL
10 mM0.2094 mL1.0469 mL2.0938 mL10.4690 mL
20 mM0.1047 mL0.5235 mL1.0469 mL5.2345 mL
50 mM0.0419 mL0.2094 mL0.4188 mL2.0938 mL
100 mM0.0209 mL0.1047 mL0.2094 mL1.0469 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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