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ALDH3A1-IN-4
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Catalog No. T212933 Copy Product Info
Purity: 99.98%
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ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC50 of 0.2 μM. ALDH3A1-IN-4 binds to the aldehyde-binding pocket of ALDH3A1 via hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 acts as a chemosensitizer that sensitizes ALDH3A1-expressing cancer cells to the antiproliferative effect of mafosfamide, but does not produce a sensitizing effect on non-cancer cells that do not express ALDH3A1. ALDH3A1-IN-4 is applicable to research related to lung adenocarcinoma and glioblastoma models, where ALDH3A1-IN-4 is used to investigate aldehyde dehydrogenase-dependent detoxification pathways, enzyme–ligand binding interactions, and differential cellular response mechanisms in tumor versus non-tumor cellular systems.
ALDH3A1-IN-4
Cas No. 324777-01-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC50 of 0.2 μM. ALDH3A1-IN-4 binds to the aldehyde-binding pocket of ALDH3A1 via hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 acts as a chemosensitizer that sensitizes ALDH3A1-expressing cancer cells to the antiproliferative effect of mafosfamide, but does not produce a sensitizing effect on non-cancer cells that do not express ALDH3A1. ALDH3A1-IN-4 is applicable to research related to lung adenocarcinoma and glioblastoma models, where ALDH3A1-IN-4 is used to investigate aldehyde dehydrogenase-dependent detoxification pathways, enzyme–ligand binding interactions, and differential cellular response mechanisms in tumor versus non-tumor cellular systems. |
| Targets & IC50 | ALDH3A1:0.2 μM |
| In vitro | Methods:Cells were treated with 10 μM ALDH3A1-IN-4 for 1 minute and 19 hours respectively. Its inhibitory effect on ALDH3A1 enzyme activity and chemosensitization effect on tumor cells were detected. Results: 1.Treatment with 10 μM ALDH3A1-IN-4 for 1 minute strongly inhibited ALDH3A1 activity in cancer cell lysates. 2.After 19-hour treatment at 10 μM, the compound selectively sensitized ALDH3A1-overexpressing A549 and SF767 cells to cyclophosphamide [1]. |
| Molecular Weight | 290.31 |
| Formula | C14H11FN2O2S |
| Cas No. | 324777-01-7 |
| Smiles | O=S(=O)(C1=CC=C(F)C=C1)N2C=3C=CC=CC3N=C2C |
| Storage | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: ALDH3A1-IN-4 in vitro | ALDH3A1-IN-4 formula | ALDH3A1-IN-4 molecular weight
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