Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively. It effectively reduces mechanical hypersensitivity [1].
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Description | AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively. It effectively reduces mechanical hypersensitivity [1]. |
In vitro | In S1R radioligand binding assays, AB21 oxalate exhibited a kinetic inhibition constant (K_i) of 12 nM without the presence of Phenytoin and 14 nM when Phenytoin was present [1]. |
In vivo | AB21 oxalate (20 mg/kg, s.c., administered 30 minutes before Capsaicin injection) reversibly counteracted the mechanical hypersensitivity in a Phenythoin-induced pain model, demonstrating higher potency compared to BD1063 dhydrochloride [1]. |
Molecular Weight | 438.52 |
Formula | C25H30N2O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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AB21 oxalate GPCR/G Protein Sigma receptor inhibitor inhibit