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Olintatug
(Synonyms: Anti-KAAG1 Antibody (ADCT-901), ADCT-901 Antibody, 3A4) Copy Product Info
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Synonyms: Anti-KAAG1 Antibody (ADCT-901), ADCT-901 Antibody, 3A4
Catalog No. T9901A-365 Copy Product Info
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Olintatug (ADCT-901) is a highly specialized antibody-drug conjugate (ADC) targeting Kidney-Associated Antigen 1 (KAAG1). It comprises a humanized monoclonal antibody conjugated to a potent pyrrolobenzodiazepine (PBD) dimer cytotoxin via a cathepsin-cleavable linker. Olintatug specifically binds to KAAG1 on tumor cell surfaces, internalizes, and releases the PBD dimer, which induces lethal DNA interstrand cross-links, blocking cell division. It is investigated for KAAG1-expressing solid tumors, including ovarian and triple-negative breast cancers.
Cas No. 2851870-28-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | 4-6 weeks | 4-6 weeks | |
| 5 mg | Inquiry | 4-6 weeks | 4-6 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Olintatug (ADCT-901) is a highly specialized antibody-drug conjugate (ADC) targeting Kidney-Associated Antigen 1 (KAAG1). It comprises a humanized monoclonal antibody conjugated to a potent pyrrolobenzodiazepine (PBD) dimer cytotoxin via a cathepsin-cleavable linker. Olintatug specifically binds to KAAG1 on tumor cell surfaces, internalizes, and releases the PBD dimer, which induces lethal DNA interstrand cross-links, blocking cell division. It is investigated for KAAG1-expressing solid tumors, including ovarian and triple-negative breast cancers. |
| In vitro | In functional assays using c-Met-expressing gastric cancer cell lines, Olintatug induced rapid receptor internalization and demonstrated potent cytotoxic activity with IC50 values in the picomolar range [1]. |
| In vivo | In gastric and colorectal cancer PDX models, systemic administration of Olintatug induced robust and sustained tumor regression in models with varying c-Met expression levels [1]. |
| Synonyms | Anti-KAAG1 Antibody (ADCT-901), ADCT-901 Antibody, 3A4 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | KAAG1 |
| Cas No. | 2851870-28-3 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Olintatug chemical structure | Olintatug in vivo | Olintatug in vitro
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