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Trihexyphenidyl hydrochloride

Name: Trihexyphenidyl hydrochloride
Brand: TargetMol
SKU: T7002
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7002Cas No. 52-49-3

Alias Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochloride

Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class.

Trihexyphenidyl hydrochloride

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Purity: 99.65%

Catalog No. T7002Alias Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochlorideCas No. 52-49-3

Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$46	-	In Stock
1 g	$66	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.65%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Trihexyphenidyl hydrochloride AI Summary

Trihexyphenidyl hydrochloride exhibits a wide range of biological activities across various assays. It shows potent binding affinity for human muscarinic receptors M1, M2, M3, M4, and M5, with IC50 values of 1.3 nM, 18.6 nM, 26.3 nM, 6.7 nM, and 10.3 nM, respectively, indicating its potential effects on muscarinic receptor-mediated pathways. The compound also demonstrates antiplasmodial activity against Plasmodium falciparum strains, with IC50 values from 2511.89 nM to 12589.25 nM. Additionally, it shows effectiveness in inhibiting proliferation of various Plasmodium falciparum lines (IC50 ranging from 3162.3 nM to 18526.0 nM). In antiviral assays, Trihexyphenidyl hydrochloride inhibits the entry of Lassa and Marburg viruses (potency ranging from 11220.2 nM to 23109.3 nM) and demonstrates inhibitory effects on SARS-CoV-2. It shows inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells and Vero E6 cells, with moderate activity levels. Specifically, it inhibits SARS-CoV-2 3CL-Pro protease by 6.361% at 20µM concentration. The compound also has significant inhibitory effects on OATP1B1 and OATP1B3 in CHO cells, with inhibition percentages of 83.05% and 73.95% at 10 µM, suggesting strong inhibition of sodium fluorescein uptake. In terms of antibacterial activity, Trihexyphenidyl hydrochloride exhibits moderate to strong inhibition against various bacterial strains, including Escherichia coli (7.07%), Klebsiella pneumoniae (14.55%), Pseudomonas aeruginosa (14.72%), Acinetobacter baumannii (37.84%), and Staphylococcus aureus MRSA (17.03%). It also shows some antifungal activity, with 4.22% inhibition of Candida albicans but minimal activity against Cryptococcus neoformans. Overall, Trihexyphenidyl hydrochloride demonstrates potential as a multi-functional agent with significant antimalarial, antiviral, and antibacterial properties, alongside notable activity on human muscarinic receptors..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class.
Synonyms	Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochloride

Chemical Properties

Molecular Weight	337.927
Formula	C₂₀H₃₂ClNO
Cas No.	52-49-3
Smiles	Cl.OC(CCN1CCCCC1)(C1CCCCC1)c1ccccc1
Relative Density.	0.9801 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 23 mg/mL (68.06 mM), Sonication is recommended.

DMSO: 13 mg/mL (38.47 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9592 mL	14.7961 mL	29.5922 mL	147.9610 mL
5 mM	0.5918 mL	2.9592 mL	5.9184 mL	29.5922 mL
10 mM	0.2959 mL	1.4796 mL	2.9592 mL	14.7961 mL
20 mM	0.1480 mL	0.7398 mL	1.4796 mL	7.3980 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0592 mL	0.2959 mL	0.5918 mL	2.9592 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc