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TH1834

Name: TH1834
Brand: TargetMol
SKU: T39554
Rating: 4.5 (1 reviews)

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Catalog No. T39554Cas No. 2108830-08-4

Alias TH-1834, TH 1834

TH1834 is a specific inhibitor of Tip60/KAT5 histone acetyltransferase. TH1834 induces apoptosis and DNA damage in breast cancer cells (MCF7) without affecting the activity of the related histone acetyltransferase MOF.

TH1834

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Purity: 99.96%

Catalog No. T39554Alias TH-1834, TH 1834Cas No. 2108830-08-4

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Purity:99.96%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TH1834 is a specific inhibitor of Tip60/KAT5 histone acetyltransferase. TH1834 induces apoptosis and DNA damage in breast cancer cells (MCF7) without affecting the activity of the related histone acetyltransferase MOF.
In vitro	TH1834, at concentrations ranging from 0 to 500 μM, acted on MCF7 cells for 1 hour, significantly reducing cell viability and enhancing cytotoxicity; at a concentration of 500 μM, it also activated caspase 3. In vitro experiments demonstrated that TH1834 exhibits significant inhibitory effects on Tip60 activity, resulting in apoptosis in breast cancer cells and an increase inunrepaired DNA damage. [1]
Synonyms	TH-1834, TH 1834

Chemical Properties

Molecular Weight	568.71
Formula	C₃₃H₄₀N₆O₃
Cas No.	2108830-08-4
Smiles	O=C(O)CN1N=NC(=N1)C2=CC=C(C=C2)CN(CCC=3C=CC=CC3)CCCCOC4=CC=C(C=C4)CN5CCCC5
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (14.07 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7584 mL	8.7918 mL	17.5837 mL	87.9183 mL
5 mM	0.3517 mL	1.7584 mL	3.5167 mL	17.5837 mL
10 mM	0.1758 mL	0.8792 mL	1.7584 mL	8.7918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc